In This Issue - pv

doi:10.1038/nchembio1005-v

Full Text - In This Issue | PDF (141 KB) - In This Issue

Meetings of the minds - p235

doi:10.1038/nchembio1005-235

Full Text - Meetings of the minds | PDF (72 KB) - Meetings of the minds

Chemical biology: an educational challenge for chemistry departments - pp236 - 238

Tadhg P Begley

doi:10.1038/nchembio1005-236

Chemical biology, broadly defined as the application of chemistry to the study of molecular events in biological systems, presents an opportunity for the reorganization and revitalization of the chemistry curriculum.

Full Text - Chemical biology: an educational challenge for chemistry departments | PDF (141 KB) - Chemical biology: an educational challenge for chemistry departments

Networking at the Protein Society Symposium - pp239 - 242

C James McKnight & Matthew H J Cordes

doi:10.1038/nchembio1005-239

From the complex behavior of multicomponent signaling networks to the structures of large protein complexes and aggregates, questions once viewed as daunting are now being tackled fearlessly by protein scientists. The 19^th Annual Symposium of the Protein Society in Boston highlighted the maturation of systems biology as applied to proteins.

Full Text - Networking at the Protein Society Symposium | PDF (305 KB) - Networking at the Protein Society Symposium

The protein modification repertoire - p243

Wilfred A van der Donk reviews Posttranslational Modifications of Proteins: Expanding Nature's Inventory by Christopher T Walsh

doi:10.1038/nchembio1005-243

Full Text - The protein modification repertoire | PDF (171 KB) - The protein modification repertoire

Decoding chemical structures from genomes - pp244 - 245

Brian O Bachmann

doi:10.1038/nchembio1005-244

Coelichelin is a new tetrapeptide siderophore from Streptomyces coelicolor originally discovered by gene sequence analysis. Surprisingly, this tetrapeptide is assembled by a trimodular nonribosomal peptide synthetase.

Full Text - Decoding chemical structures from genomes | PDF (184 KB) - Decoding chemical structures from genomes

See also: Letter by Lautru et al.

Nitrite as an intrinsic signaling molecule - pp245 - 246

Mark T Gladwin

doi:10.1038/nchembio1005-245

Nitrite, a ubiquitous stable oxidation byproduct of nitric oxide (NO) metabolism, is now entering the pantheon of signaling biochemical molecules. Nitrite may have the unique properties of a blood and tissue NO reservoir activated by physiological and pathological hypoxia.

Full Text - Nitrite as an intrinsic signaling molecule | PDF (128 KB) - Nitrite as an intrinsic signaling molecule

See also: Article by Bryan et al.

Lox and Cre sandwich - pp246 - 247

Linda Lee & Paul D Sadowski

doi:10.1038/nchembio1005-246

Unlike many site-specific recombinases that require accessory proteins, the Cre recombinase itself organizes a synaptic complex to initiate the recombination reaction. A new study suggests how Cre recombinase accomplishes this catalytic feat.

Full Text - Lox and Cre sandwich | PDF (184 KB) - Lox and Cre sandwich

See also: Article by Ghosh et al.

Targeted antioxidant delivery prolongs sperm lifespan - pp248 - 249

Eilish T Donnelly

doi:10.1038/nchembio1005-248

The high polyunsaturated fatty acid content of mammalian sperm cell membranes makes them vulnerable to damaging oxidation. A carbohydrate-antioxidant polymer has been developed that greatly increases antioxidant levels in sperm, counteracting any detrimental effects and improving sperm function.

Full Text - Targeted antioxidant delivery prolongs sperm lifespan | PDF (96 KB) - Targeted antioxidant delivery prolongs sperm lifespan

See also: Letter by Fleming et al.

Research Highlights - p251

doi:10.1038/nchembio1005-251

Full Text - Research Highlights | PDF (115 KB) - Research Highlights