News and Views
Nature Chemical Biology 1, 246 - 247 (2005)
doi:10.1038/nchembio1005-246
Lox and Cre sandwich
- Linda Lee is in the Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720-3202. e-mail: linlee@berkeley.edu
- Paul D. Sadowski is in the Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. e-mail: p.sadowski@utoronto.ca
Abstract
Unlike many site-specific recombinases that require accessory proteins, the Cre recombinase itself organizes a synaptic complex to initiate the recombination reaction. A new study suggests how Cre recombinase accomplishes this catalytic feat.
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