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Nature Chemical Biology 1, 245 - 246 (2005)
doi:10.1038/nchembio1005-245
Nitrite as an intrinsic signaling molecule
Mark T Gladwin1
- Mark T. Gladwin is in the Vascular Medicine Branch of the National Heart, Lung, and Blood Institute at the US National Institutes of Health, Bethesda, Maryland 20892, USA. e-mail: mgladwin@nih.gov
Abstract
Nitrite, a ubiquitous stable oxidation byproduct of nitric oxide (NO) metabolism, is now entering the pantheon of signaling biochemical molecules. Nitrite may have the unique properties of a blood and tissue NO reservoir activated by physiological and pathological hypoxia.
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