News and Views
Nature Chemical Biology 1, 185 - 186 (2005)
doi:10.1038/nchembio0905-185
Antigene leaps forward through an open door
Bruce A Armitage1
- Bruce A. Armitage is in the Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA. e-mail: army@andrew.cmu.edu.
Abstract
Blocking gene expression by interfering with translation of mRNA can be accomplished by means of antisense or short interfering RNA strategies, but more potent inhibitors would act by inhibiting transcription of genomic DNA. Two new studies show efficient inhibition of transcription using single-stranded peptide nucleic acid or double-stranded RNA targeted to the open complex formed at the transcription start site.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acidsNature Chemical Biology Article (01 Sep 2005)
Enhancement of strand invasion by oligonucleotides through manipulation of backbone chargeNature Biotechnology Research Article (01 Dec 1996)
Inhibition of human telomerase activity by peptide nucleic acidsNature Biotechnology Research Article (01 May 1996)
See all 5 matches for Research
