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Letter
Nature Chemical Biology 1, 146–148 (1 August 2005) | doi:10.1038/nchembio718
High-throughput assays for promiscuous inhibitors
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Abstract
High-throughput screening (HTS) searches large libraries of chemical compounds for those that can modulate the activity of a particular biological target; it is the dominant technique used in early-stage drug discovery. A key problem in HTS is the prevalence of nonspecific or 'promiscuous' inhibitors.
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