1. Steven R. Tannenbaum is in the Division of Biological Engineering and Department of Chemistry, and Ji-Eun Kim is in the Division of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. e-mail: SRT@mit.edu.

Abstract

Protein nitrosation is an important signaling mechanism in vivo; however, mechanisms for selective nitric oxide modification of cysteines have not been described. Thioredoxin is now shown to rapidly and site-specifically catalyze S-nitrosation of an active site cysteine of caspase-3.

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