In This Issue - p61
doi:10.1038/nchembio0705-61
Table of contents
July 2005, Volume 1 No 2 pp61-119
About the coverTop of page
Editorial
Nature Chemical Biology features - p63
doi:10.1038/nchembio0705-63
Full Text - Nature Chemical Biology features | PDF (75 KB) - Nature Chemical Biology features
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Commentary
Small molecules: the missing link in the central dogma - pp64 - 66
Stuart L Schreiber
doi:10.1038/nchembio0705-64
Small molecules have critical roles at all levels of biological complexity and yet remain orphans of the central dogma. Chemical biologists, working with small molecules, expand our understanding of these central elements of life.
Full Text - Small molecules: the missing link in the central dogma | PDF (279 KB) - Small molecules: the missing link in the central dogma
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News and Views
Viral RNA gymnastics - pp67 - 68
Valerie Calabro & Alan D Frankel
doi:10.1038/nchembio0705-67
Retroviruses have a stretch of RNA that dimerizes during viral particle formation. A new study suggests that RNA flexibility in the monomeric form may facilitate dimerization or other RNA-dependent viral functions.
Full Text - Viral RNA gymnastics | PDF (136 KB) - Viral RNA gymnastics
See also: Article by Badorrek & Weeks
Probing cell death by chemical screening - pp68 - 69
David Wallach
doi:10.1038/nchembio0705-68
Apoptosis occurs through precise cellular pathways, whereas necrosis is generally thought of as a nonspecific cellular response to external damage. However, identification of a chemical inhibitor of necrotic events suggests that specific molecular pathways can also trigger necrosis.
Full Text - Probing cell death by chemical screening | PDF (197 KB) - Probing cell death by chemical screening
See also: Article by Degterev et al.
A photochemical snapshot of CD22 binding - pp69 - 70
Kevin J Yarema & Zhonghui Sun
doi:10.1038/nchembio0705-69
Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.
Full Text - A photochemical snapshot of CD22 binding | PDF (232 KB) - A photochemical snapshot of CD22 binding
See also: Letter by Han et al.
Relaxed specificity in aromatic prenyltransferases - pp71 - 72
Patrice Koehl
doi:10.1038/nchembio0705-71
Prenylation represents a critical step in the biosynthesis of many natural products. A new study reveals how aromatic prenyltransferase enzymes tolerate diverse aromatic polyketides while still controlling the length of prenyl side chains.
Full Text - Relaxed specificity in aromatic prenyltransferases | PDF (166 KB) - Relaxed specificity in aromatic prenyltransferases
Research Highlights - p73
doi:10.1038/nchembio0705-73
Full Text - Research Highlights | PDF (225 KB) - Research Highlights
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Reviews
Diversity-oriented synthesis: exploring the intersections between chemistry and biology - pp74 - 84
Derek S Tan
doi:10.1038/nchembio0705-74
Abstract - Diversity-oriented synthesis: exploring the intersections between chemistry and biology | Full Text - Diversity-oriented synthesis: exploring the intersections between chemistry and biology | PDF (1,973 KB) - Diversity-oriented synthesis: exploring the intersections between chemistry and biology
Sensing with TRP channels - pp85 - 92
Thomas Voets, Karel Talavera, Grzegorz Owsianik & Bernd Nilius
doi:10.1038/nchembio0705-85
Abstract - Sensing with TRP channels | Full Text - Sensing with TRP channels | PDF (823 KB) - Sensing with TRP channels
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Letters
Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking - pp93 - 97
Shoufa Han, Brian E Collins, Per Bengtson & James C Paulson
doi:10.1038/nchembio713
First Paragraph - Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking | Full Text - Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking | PDF (365 KB) - Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking | Supplementary information | Chemical compounds
See also: News and Views by Yarema & Sun
Linking agonist binding to histamine H1 receptor activation - pp98 - 103
Aldo Jongejan, Martijn Bruysters, Juan A Ballesteros, Eric Haaksma, Remko A Bakker, Leonardo Pardo & Rob Leurs
doi:10.1038/nchembio714
First Paragraph - Linking agonist binding to histamine H: 1: receptor activation | Full Text - Linking agonist binding to histamine H1 receptor activation | PDF (434 KB) - Linking agonist binding to histamine H1 receptor activation | Supplementary information | Chemical compounds
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Top of pageArticles
RNA flexibility in the dimerization domain of a gamma retrovirus - pp104 - 111
Christopher S Badorrek & Kevin M Weeks
doi:10.1038/nchembio712
Abstract - RNA flexibility in the dimerization domain of a gamma retrovirus | Full Text - RNA flexibility in the dimerization domain of a gamma retrovirus | PDF (442 KB) - RNA flexibility in the dimerization domain of a gamma retrovirus | Supplementary information | Chemical compounds
See also: News and Views by Calabro & Frankel
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury - pp112 - 119
Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz & Junying Yuan
doi:10.1038/nchembio711
Abstract - Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury | Full Text - Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury | PDF (509 KB) - Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury | Supplementary information | Chemical compounds
See also: News and Views by Wallach
