Figure 1 - Phylogeny and architecture of TRP channels.

From the following article

Sensing with TRP channels

Thomas Voets, Karel Talavera, Grzegorz Owsianik & Bernd Nilius

Nature Chemical Biology 1, 85 - 92 (2005)


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(a) Phylogenetic relationships between members of the human TRP-channel superfamily. The multiple-alignment phylogenetic tree illustrates the relation between the different TRP subfamilies. Phenograms were generated independently for each subfamily. Note that TRPC2 is a pseudogene in primates and that TRPN channels have not been identified in mammals. (b) Top, proposed architecture of TRPV6. The pore region is formed by the loop between TM5 and TM6, which forms the pore helix and selectivity filter18 similar to that of K+ channels16. The structures of TM1–TM4 are currently unknown. Four identical or similar subunits form a functional channel (for clarity, only two subunits are shown). Bottom, overview of structural motifs found in the N- and C-terminal tails of the different TRP subfamilies. The number of motif repeats is given in brackets. The structural motifs in the cytosolic tails of members of the TRPML, TRPP, TRPN and TRPA subfamilies are not always known, hence the question marks.