News and Views
Nature Chemical Biology 1, 69 - 70 (2005)
doi:10.1038/nchembio0705-69
A photochemical snapshot of CD22 binding
Kevin J Yarema1 & Zhonghui Sun1
- Kevin J. Yarema and Zhonghui Sun are in the Department of Biomedical Engineering, The Johns Hopkins University, Clark Hall 106A, 3400 North Charles Street, Baltimore, Maryland 21218, USA. e-mail: kjyarema@bme.jhu.edu
Abstract
Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.
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