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Nature Chemical Biology 1, 69 - 70 (2005)
doi:10.1038/nchembio0705-69

A photochemical snapshot of CD22 binding

Kevin J Yarema1 & Zhonghui Sun1

  1. Kevin J. Yarema and Zhonghui Sun are in the Department of Biomedical Engineering, The Johns Hopkins University, Clark Hall 106A, 3400 North Charles Street, Baltimore, Maryland 21218, USA. e-mail: kjyarema@bme.jhu.edu


Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.

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