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In This Issue

In This Issue p1

doi:10.1038/nchembio0605-1


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Editorial

A community of chemists and biologists p3

doi:10.1038/nchembio0605-3


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News and Views

Ribonucleic general acid pp5 - 6

Scott A Strobel

doi:10.1038/nchembio0605-5

Ribozymes are enzymes comprised of RNA that fold into three-dimensional structures and that catalyze chemical reactions central to all cells. A new study shows that ribozymes, like proteins, may use general acid catalysis as part of their catalytic toolkit.

See also: Article by Das & Piccirilli


Pulling NO out of thin air pp6 - 7

Thomas G Spiro

doi:10.1038/nchembio0605-6

Nitric oxide signaling requires that the heme of soluble guanylate cyclase bind NO preferentially to O2. Engineering of the enzyme's active site reveals a molecular basis for NO binding selectivity.

See also: Article by Boon et al.


Trp modification signals a quorum pp7 - 8

Richard A Gibbs

doi:10.1038/nchembio0605-7

ComX is a post-translationally modified peptide involved in quorum sensing in Bacillus subtilis. The structure of ComX has now been shown to contain a geranylated tryptophan with an unusual tricyclic architecture.

See also: Brief Communication by Okada et al.


Ending the prolonged life of cancer cells pp8 - 9

Gerhard Wagner

doi:10.1038/nchembio0605-8

The fate of cells depends on a delicate balance of pro- and anti-apoptotic proteins. Small-molecule inhibitors of anti-apoptotic protein-protein interactions promote apoptosis in cancer cells.


Research Highlights p11

doi:10.1038/nchembio0605-11


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Review

Chemistry in living systems pp13 - 21

Jennifer A Prescher & Carolyn R Bertozzi

doi:10.1038/nchembio0605-13


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Brief Communication

Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX pp23 - 24

Masahiro Okada, Isao Sato, Soo Jeong Cho, Hidehisa Iwata, Toshihiko Nishio, David Dubnau & Youji Sakagami

doi:10.1038/nchembio709

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See also: News and Views by Gibbs


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Letters



Activity-based probes that target diverse cysteine protease families pp33 - 38

Daisuke Kato, Kelly M Boatright, Alicia B Berger, Tamim Nazif, Galia Blum, Ciara Ryan, Kareem A H Chehade, Guy S Salvesen & Matthew Bogyo

doi:10.1038/nchembio707

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Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats pp39 - 43

Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima & Chojiro Kojima

doi:10.1038/nchembio708

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