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Trp modification signals a quorum

ComX is a post-translationally modified peptide involved in quorum sensing in Bacillus subtilis. The structure of ComX has now been shown to contain a geranylated tryptophan with an unusual tricyclic architecture.

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Figure 1: Two different flavors of peptide prenylation.

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Gibbs, R. Trp modification signals a quorum. Nat Chem Biol 1, 7–8 (2005). https://doi.org/10.1038/nchembio0605-7

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