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  • Article |

    Strains of Escherichia coli, each expressing a subset of the 34 translation machinery proteins, are grown in synthetic microbial consortia to enable the efficient isolation of the full machinery from a single culturing, lysis, and purification procedure.

    • Fernando Villarreal
    • , Luis E Contreras-Llano
    • , Michael Chavez
    • , Yunfeng Ding
    • , Jinzhen Fan
    • , Tingrui Pan
    •  & Cheemeng Tan
  • Article |

    Engineering of nonimmune cells with a cell-contact sensor and antigen recognition domains enables cell-contact-dependent sensor cell signaling and effector molecule production directed to attack target cells, providing an alternative strategy to chimeric antigen receptor T-cell (CAR-T) technology.

    • Ryosuke Kojima
    • , Leo Scheller
    •  & Martin Fussenegger
  • Article |

    A multistage tandem mass spectrometry approach enables the application of native proteomics to characterize intact endogenous protein complexes in discovery mode, including covalent modifications as well as noncovalently bound cofactors and ligands.

    • Owen S Skinner
    • , Nicole A Haverland
    • , Luca Fornelli
    • , Rafael D Melani
    • , Luis H F Do Vale
    • , Henrique S Seckler
    • , Peter F Doubleday
    • , Luis F Schachner
    • , Kristina Srzentić
    • , Neil L Kelleher
    •  & Philip D Compton
  • Article |

    Mass-spectrometry-based metabolomics analysis of oligodendrocyte differentiation led to the identification of an endogenous metabolite, taurine, that enhanced the process of drug-induced OPC differentiation.

    • Brittney A Beyer
    • , Mingliang Fang
    • , Benjamin Sadrian
    • , J Rafael Montenegro-Burke
    • , Warren C Plaisted
    • , Bernard P C Kok
    • , Enrique Saez
    • , Toru Kondo
    • , Gary Siuzdak
    •  & Luke L Lairson
  • Article |

    In organohalide-respiring bacteria, reductive dehalogenases cleave carbon–halogen bonds using cobamide prosthetic groups. Desulfitobacterium hafniense uses an unprecedented cobamide variant, which includes unsubstituted purine, for this function.

    • Jun Yan
    • , Meng Bi
    • , Allen K Bourdon
    • , Abigail T Farmer
    • , Po-Hsiang Wang
    • , Olivia Molenda
    • , Andrew T Quaile
    • , Nannan Jiang
    • , Yi Yang
    • , Yongchao Yin
    • , Burcu Şimşir
    • , Shawn R Campagna
    • , Elizabeth A Edwards
    •  & Frank E Löffler
  • Article |

    Ultrasensitive imaging of lanthanide chelates is achieved by integrating transreflected illumination, luminescence resonance energy transfer, and time-resolved microscopy.

    • Ukrae Cho
    • , Daniel P Riordan
    • , Paulina Ciepla
    • , Kiranmai S Kocherlakota
    • , James K Chen
    •  & Pehr B Harbury

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