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Enzymatic catalysis

New functional twists for P450s

Nature Chemistry volume 9, pages 609–611 (2017)Cite this article

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Two papers provide insight into the reactivity of cytochrome P450s. A direct link between electron donation and reactivity has been shown with a selenocysteine-ligated P450 compound I, whereas a serine-ligated P450 (P411) has been engineered to catalyse an intermolecular C–H amination via nitrene transfer.

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Figure 1: Substitution of the heme-coordinating cysteine residue in P450s provides a point of entry for investigating the native reactivity of these enzymes as well as developing new chemical reactivity.

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Authors and Affiliations

  1. Rudi Fasan is in the Department of Chemistry, 416 Hutchison Hall, RC Box 270216, University of Rochester, Rochester, New York 14627-0216, USA,

    Rudi Fasan

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  1. Rudi Fasan
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Correspondence to Rudi Fasan.

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Fasan, R. New functional twists for P450s. Nature Chem 9, 609–611 (2017). https://doi.org/10.1038/nchem.2810

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