Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Synthesis and the Nobel Prize in Chemistry

The question often arises as to who may have deserved a Nobel Prize but was not awarded one. Rarely is this discussion extended to who should have received more than one Nobel Prize, but in the field of organic synthesis there are some compelling candidates.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

HUP WOODWARD, ROBERT BURNS (8),OLVWORK727971. HARVARD UNIVERSITY ARCHIVES

Figure 2: R. B. Woodward's published achievements in three areas of organic chemistry as a function of time: structure determinations (in red), total syntheses (in blue), and structure and mechanism 'rules' (in green).
Figure 3: E. J. Corey's number of publications reached a maximum in the mid-1980s.

References

  1. Hargittai, I. The Road to Stockholm. Nobel Prizes, Science, and Scientists (Oxford Univ. Press, 2002).

    Google Scholar 

  2. McGrayne, S. B. Nobel Prize Women in Science: Their Lives, Struggles, and Momentous Discoveries (Birch Lane Press, 1992).

    Google Scholar 

  3. Friedman, R. M. The Politics of Excellence: Behind the Nobel Prize in Science (W. H. Freeman, 2001).

    Google Scholar 

  4. Seeman, J. I. in The Posthumous Nobel Prize in Chemistry (eds Strom, E. T. & Mainz, V.) (American Chemical Society, 2017).

    Google Scholar 

  5. B.R.S.M. Woodward Wednesday 4: and all that could have been. B.R.S.M. Blog http://brsmblog.com/woodward-wednesday-4-and-all-that-could-have-been/ (19 April 2012).

  6. Benfey, O. T. & Morris, P. J. T. Robert Burns Woodward. Architect and Artist in the World of Molecules (Chemical Heritage Foundation, 2001).

    Google Scholar 

  7. Seeman, J. I. Angew. Chem. Int. Ed. 55, 12898–12912 (2016).

    Article  CAS  Google Scholar 

  8. Lord Todd & Cornforth, J. W. Biogr. Mem. Fellows R. Soc. 27, 629–695 (1981).

    Google Scholar 

  9. Blout, E. in Biographical Memoirs of the National Academy of Sciences Vol. 80, 2–23 (National Academy Press, 2001).

    Google Scholar 

  10. Seeman, J. I. Angew. Chem. Int. Ed. 56, 10228–10245 (2017).

    Article  CAS  Google Scholar 

  11. Woodward, R. B., Brehm, W. J. & Nelson, A. L. J. Am. Chem. Soc. 69, 2250 (1947).

    Article  CAS  Google Scholar 

  12. Openshaw, H. T. & Robinson, R. Nature 157, 438 (1946).

    Article  CAS  Google Scholar 

  13. Johnson, J. R., Robinson, R. & Woodward, R. B. in The Chemistry of Penicillin (eds Clarke, H. T., Johnson, J. R. & Robinson, R.) 440–454 (Princeton Univ. Press, 1949).

    Book  Google Scholar 

  14. Bentley, R. J. Chem. Educ. 81, 1462–1470 (2004).

    Article  CAS  Google Scholar 

  15. Wilkinson, G., Rosenblum, M., Whiting, M. C. & Woodward, R. B. J. Am. Chem. Soc. 74, 2125–2126 (1952).

    Article  CAS  Google Scholar 

  16. Seeman, J. I. & Cantrill, S. Nat. Chem. 8, 193–200 (2016).

    Article  CAS  Google Scholar 

  17. Woodward, R. B., Brutschy, F. J. & Baer, H. J. Am. Chem. Soc. 70, 4216–4221 (1948).

    Article  CAS  Google Scholar 

  18. Woodward, R. B. & Brehm, W. J. J. Am. Chem. Soc. 69, 2107–2115 (1948).

    Article  Google Scholar 

  19. Barton, D. H. R., Jeger, O., Prelog, V. & Woodward, R. B. Experientia 10, 81–90 (1954).

    Article  CAS  Google Scholar 

  20. Woodward, R. B. & Singh, G. Experientia 6, 238–240 (1950).

    Article  CAS  Google Scholar 

  21. Woodward, R. B. in Festschrift Arhtur Stoll zum siebzigsten Geburtstag, 8 January 1957 524–544 (Birkhäuser, 1957).

    Google Scholar 

  22. Seeman, J. I. Chem. Eng. News 91, Front cover; 10–11; 13–14 (2013).

    Google Scholar 

  23. Djerassi, C. Carl Djerassi in Retrospect: From the Pill to the Pen (Imperial College Press, 2014).

    Book  Google Scholar 

  24. Laszlo, P. Ambix 57, 202–215 (2010).

    Article  CAS  Google Scholar 

  25. Corey, E. J., Ohno, M., Mitra, R. B. & Vatakencherry, P. A. J. Am. Chem. Soc. 86, 478–485 (1964).

    Article  CAS  Google Scholar 

  26. Corey, E. J. Angew. Chem. Int. Ed. 30, 455–464 (1990).

    Article  Google Scholar 

  27. Li, J. & Eastgate, M. D. Org. Biomol. Chem. 13, 7164–7176 (2015).

    Article  CAS  Google Scholar 

  28. Gasteiger, J. Nat. Chem. 7, 619–620 (2015).

    Article  CAS  Google Scholar 

  29. Woodward, R. B. et al. J. Am. Chem. Soc. 76, 4749–4751 (1954).

    Article  CAS  Google Scholar 

  30. Nicolaou, K. C., Vourloumis, D., Winssinger, N. & Baran, P. S. Angew. Chem. Int. Ed. 39, 44–122 (2000).

    Article  CAS  Google Scholar 

  31. Nicolaou, K. C. Angew. Chem. Int. Ed. 52, 131–146 (2013).

    Article  CAS  Google Scholar 

  32. Friedman, R. M. Nature 292, 793–798 (1981).

    Article  CAS  Google Scholar 

  33. Friedman, R. M. Hist. Stud. Phys. Biol. Sci. 20, 63–77 (1989).

    Article  CAS  Google Scholar 

  34. Friedman, R. M. The cult of the Nobel: time for a change. Georgetown Journal of International Affairs http://journal.georgetown.edu/the-cult-of-the-nobel-time-for-a-change/ (19 February 2016).

  35. Kauffman, G. B. Angew. Chem. Int. Ed. 42, 1194–1196 (2003).

    Article  CAS  Google Scholar 

  36. Seeman, J. I. Chem. Eng. News 92, 38–39 (2014).

    Google Scholar 

  37. Djerassi, C. Der Schattensammler. Die allerletzte Autobiografie (Treading on Shadows. The Very Last Autobiography) (Haymon–Verlag, 2013).

    Google Scholar 

  38. Hoffmann, R. Angew. Chem. Int. Ed. 51, 1734–1735 (2012).

    Article  CAS  Google Scholar 

  39. Feynman, R. J Microelectromech. Sys. 2, 4–14 (1993).

    Article  Google Scholar 

  40. Feynman, R. Eng. Sci. XXIII, 22–36 (1960).

    Google Scholar 

  41. Zydowsky, T. M. Chem. Intell. 6, 29–34 (2000).

    CAS  Google Scholar 

Download references

Acknowledgements

The author thanks E. J. Corey, R. Hoffmann, and K. C. Nicolaou for helpful discussions and K. Donald for technical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jeffrey I. Seeman.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seeman, J. Synthesis and the Nobel Prize in Chemistry. Nature Chem 9, 925–929 (2017). https://doi.org/10.1038/nchem.2864

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.2864

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing