A quantitative understanding of the functional landscape of a biochemical circuit can reveal the design rules required to optimize the circuit. Now, a high-throughput droplet-based microfluidic platform has been developed which enables high-resolution mapping of bifurcation diagrams for two nonlinear DNA networks.
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References
Hariadi, R. F. et al. Nature Nanotech. 10, 696–700 (2015).
Douglas, S. M., Bachelet, I. & Church, G. M. Science 335, 831–834 (2012).
Adleman, L. M. Science 266, 1021–1024 (1994).
Benenson, Y. Nature Rev. Genetics 13, 455–468 (2012).
Qian, L. & Winfree, E. Science 332, 1196–1201 (2011).
Zhang, D. Y. & Winfree, E. J. Am. Chem. Soc. 131, 17303–17314 (2009).
Hasatani, K. et al. Chem. Commun. 49, 8090–8092 (2013).
Genot, A. J. et al. Nature Chem. 8, 760–767 (2016).
Padirac, A., Fujii, T. & Rondelez, Y. Proc. Natl Acad. Sci. USA 109, 4–6 (2012).
Fujii, T. & Rondelez, Y. ACS Nano 7, 27–34 (2012).
Regot, S. et al. Nature 469, 207–211 (2011).
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Wang, F., Fan, C. Providing a panoramic view. Nature Chem 8, 738–740 (2016). https://doi.org/10.1038/nchem.2583
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DOI: https://doi.org/10.1038/nchem.2583
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