A new click-style reaction based on a strain-release amination strategy has been developed. This approach can be used to append small, strained ring systems onto a core scaffold.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
How mono- and diphosphine ligands alter regioselectivity of the Rh-catalyzed annulative cleavage of bicyclo[1.1.0]butanes
Nature Communications Open Access 26 November 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kolb, H. C., Finn, M. G. & Sharpless, K. B. Angew. Chem. Int. Ed. 40, 2004–2021 (2001).
Wiberg, K. B. Angew. Chem. Int. Ed. Engl. 25, 312–322 (1986).
De Meijere, A., Kozhushkov, S. I. & Schill, H. Chem. Rev. 106, 4926–4996 (2006).
Gianatassio, R. et al. Science 351, 241–246 (2016).
Schreiber, S. L. Science 287, 1964–1969 (2000).
Walczak, M. A. A., Krainz, T. & Wipf, P. Acc. Chem. Res. 48, 1149–1158 (2015).
Yu, L., Liu, M., Chen, F. & Xu, Q. Org. Biomol. Chem. 13, 8379–8392 (2015).
Petronijevic, F. R. & Wipf, P. J. Am. Chem. Soc. 133, 7704–7707 (2011).
Chen, K., Sun, R., Wei, Y. & Shi, M. Org. Biomol. Chem. 11, 3949–3953 (2013).
Brown, D. et al. J. Chem. Soc. Perkin Trans. 1 2014–2021 (2002).
Nicolaou, K. C. et al. J. Am. Chem. Soc. 138, 1698–1708 (2016).
Lovering, F., Bikker, J. & Humblet, C. J. Med. Chem. 52, 6752–6756 (2009).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Milligan, J., Wipf, P. Straining to react. Nature Chem 8, 296–297 (2016). https://doi.org/10.1038/nchem.2485
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.2485
