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Carbohydrate reactivity

Glycosyl cations out on parole

The reactivity of glycosyl donors is often explained by invoking putative glycosyl cation intermediates but, until now, they have not been observed in the condensed phase.

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Figure 1: Oxocarbenium ions and their role in glycosylation.

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Correspondence to David Crich.

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Bohé, L., Crich, D. Glycosyl cations out on parole. Nature Chem 8, 99–100 (2016). https://doi.org/10.1038/nchem.2436

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