About the cover

February 2016 Volume 8 No 2

The mechanism by which RNA and proteins form liquid organelles is not fully understood, but William Aumiller Jr and Christine Keating have now demonstrated that charge-mediated phase separation can generate droplets that resemble a simple model of these assemblies. By controlling the phosphorylation of cationic peptides using a kinase/phosphatase enzyme pair, Aumiller and Keating were able to reversibly form and dissolve liquid droplets from the peptides and RNA. The cover image depicts the formation of liquid organelles of different sizes.

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IMAGE: CHRISTINE KEATING AND WILLIAM AUMILLER JR

COVER DESIGN: KAREN MOORE