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November 2015 Volume 7 No 11

Short amphiphilic foldamers featuring an oligourea backbone with typical amino-acid side chains have been shown to self-assemble in water to form well-defined three-dimensional structures. By changing the sequence of the oligoureas — and hence the arrangement of different side chains when folded into a helical conformation — Gilles Guichard and co-workers are able to programme the system to form either discrete helical bundles containing isolated cavities, or pH-responsive water-filled channels with controllable pore diameters (an example of the latter is shown conceptually on the cover).

Article p871; News & Views p858

MAIN IMAGE: GAVIN W. COLLIE, CAMERON MACKERETH AND GILLES GUICHARD BACKGROUND IMAGE: AUIMEESRI/THINKSTOCK/ISTOCK

COVER DESIGN: KAREN MOORE

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