Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Helicates

Making head–head–tails of it

Enantiomerically pure head-to-head-to-tail triple-stranded helicates synthesized using a subcomponent self-assembly approach possess high anticancer activities against cancer cell lines without significant damage to DNA and with low toxicity to bacteria.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The structure of head-to-head-to-tail triple-stranded helicates.

References

  1. Lehn, J.-M. et al. Proc. Natl Acad. Sci. USA 84, 2565–2569 (1987).

    Article  CAS  Google Scholar 

  2. Maayan, G. & Albrecht, M. (eds) Metallofoldamers - Supramolecular Architectures from Helicates to Biomimetics (Wiley, 2013).

    Book  Google Scholar 

  3. Hannon, M. J. et al. Angew. Chem. Int. Ed. 40, 879–884 (2001).

    Article  Google Scholar 

  4. Faulkner, A. D. et al. Nature Chem. 6, 797–803 (2014).

    Article  CAS  Google Scholar 

  5. Ronson, T. K., Zarra, S., Black, S. P. & Nitschke, J. R. Chem. Commun. 49, 2476–2490 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Markus Albrecht.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Albrecht, M. Making head–head–tails of it. Nature Chem 6, 761–762 (2014). https://doi.org/10.1038/nchem.2040

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.2040

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing