About the cover

July 2014 Volume 6 No 7

Proteins can adopt many conformations at room temperature, which creates a problem for those trying to find complementary ligands. Now, James S. Fraser, Brian K. Shoichet and colleagues have developed a computational method that represents the conformational behaviour of proteins in docking screens. An artistic impression of the docking of nine newly discovered ligands within a protein binding site is shown on the cover; the panels are arranged in pairs and depict either a prediction of a particular ligand-protein interaction (upper) or the corresponding crystallographic data (lower).

Article p575; News & Views p560

IMAGE: RYAN G. COLEMAN

COVER DESIGN: ALEX WING