The lomaiviticins are exceedingly potent antibiotic agents, but the mechanism responsible for this activity has so far been unclear. Now, efficient generation of double-strand breaks in DNA by lomaiviticin A has been linked to the remarkable cytotoxicity of these diazobenzofluorene-containg natural products.
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Gates, K. DNA double whammy. Nature Chem 6, 464–465 (2014). https://doi.org/10.1038/nchem.1965
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DOI: https://doi.org/10.1038/nchem.1965
