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Thesis

Faith, chemistry and extraterrestrial life pp943 - 944

Bruce C. Gibb

doi:10.1038/nchem.2094

Bruce Gibb wonders whether our faith in chemistry — and what it can teach us about the Universe beyond our Earthly bounds — will have a role to play in the search for alien life.


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Books and Arts

A spoonful of curiosity p945

Catherine Goodman reviews A Taste of Molecules by Diane Fresquez

doi:10.1038/nchem.2100


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Blogroll

Blogroll: Hot and sweet p947

Kat Day

doi:10.1038/nchem.2091


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News and Views

Light-harvesting materials: Soft support for energy conversion pp949 - 950

Ryan M. Stolley & Monte L. Helm

doi:10.1038/nchem.2088

To convert solar energy into viable fuels, coupling light-harvesting materials to catalysts is a crucial challenge. Now, the combination of an organic supramolecular hydrogel and a non-precious metal catalyst has been demonstrated to be effective for photocatalytic H2 production.

See also: Article by Weingarten et al.


Molecular topology: Star-crossed self-assembly pp950 - 952

Guido H. Clever

doi:10.1038/nchem.2065

Interwoven supramolecular structures are often held up as examples of beauty in chemistry, but these assemblies can be fragile depending on the environments they are exposed to. Post-assembly covalent modification can, however, trap them in robust molecular form, and a triply entwined [2]catenane is one of the most sophisticated examples so far.

See also: Article by Leigh et al.


Frustrated Lewis pairs: A metal-free landmark pp952 - 953

Douglas W. Stephan

doi:10.1038/nchem.2093

The synthesis and isolation of a silane adduct of an electrophilic boron species provides insight into the mechanism of metal-free catalytic reductions based on frustrated Lewis pairs.

See also: Article by Houghton et al.


Metal–organic frameworks: 3D frameworks from 3D printers pp953 - 954

Ian D. Williams

doi:10.1038/nchem.2089

High-throughput screening of solvothermal crystallization conditions for MOFs and other solids may receive a boost from the application of 3D printing techniques to low-cost, disposable pressure vessels.


Photochemistry: A bright future for sunscreens pp955 - 956

Vasilios G. Stavros

doi:10.1038/nchem.2084

Understanding the intrinsic properties of molecules that protect our skin from the harmful rays of the Sun is critical to developing more efficacious sunscreen products. Now, gas-phase spectroscopy and microsolvation studies of model ultraviolet-filter molecules have shown that they may provide a route to developing improved sunscreens.


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Articles

Non-oxidative intercalation and exfoliation of graphite by Brønsted acids pp957 - 963

Nina I. Kovtyukhova, Yuanxi Wang, Ayse Berkdemir, Rodolfo Cruz-Silva, Mauricio Terrones, Vincent H. Crespi & Thomas E. Mallouk

doi:10.1038/nchem.2054

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Intercalation in graphite is generally driven by partial oxidation or reduction of the graphene sheets. Now, it has been shown that graphite microcrystals can be intercalated by Brønsted acids by heating a liquid suspension to dryness. The intercalated acid molecules interact weakly with the carbon sheets but assist in their exfoliation to single- and few-layer graphene.


Self-assembling hydrogel scaffolds for photocatalytic hydrogen production pp964 - 970

Adam S. Weingarten, Roman V. Kazantsev, Liam C. Palmer, Mark McClendon, Andrew R. Koltonow, Amanda P. S. Samuel, Derek J. Kiebala, Michael R. Wasielewski & Samuel I. Stupp

doi:10.1038/nchem.2075

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Self-assembled ribbons of perylene amphiphiles have been shown to crystallize in the presence of a nickel-based hydrogen production catalyst, allowing efficient electronic coupling between the perylene chromophores. This hydrogel material photocatalyses the production of H2, and can be shaped and placed on surfaces for incorporation into devices.

See also: News and Views by Stolley & Helm


Chiral self-sorting and amplification in isotropic liquids of achiral molecules pp971 - 977

Christian Dressel, Tino Reppe, Marko Prehm, Marcel Brautzsch & Carsten Tschierske

doi:10.1038/nchem.2039

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The spontaneous resolution of racemic mixtures can occur when the molecules are confined in a crystal lattice, on surfaces or in other well-ordered assemblies. Now, mirror symmetry breaking within an isotropic liquid of achiral molecules has been observed. These liquids show strong chiral amplification and provide a possible mode of emergence of chirality in prebiotic fluids.


A Star of David catenane pp978 - 982

David A. Leigh, Robin G. Pritchard & Alexander J. Stephens

doi:10.1038/nchem.2056

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The Star of David topology is an iconic symbol that has been used in religious and cultural contexts for thousands of years. Now it is assembled in molecular form through a hexameric circular helicate generated by six tris(bipyridine) ligands entwined about six iron(II) cations. The structure of the two triply-entwined 114-membered rings is revealed by X-ray crystallography.

See also: News and Views by Clever


Direct observation of a borane–silane complex involved in frustrated Lewis-pair-mediated hydrosilylations pp983 - 988

Adrian Y. Houghton, Juha Hurmalainen, Akseli Mansikkamäki, Warren E. Piers & Heikki M. Tuononen

doi:10.1038/nchem.2063

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Comprehensive solution and solid-state characterization of an adduct between a Lewis acidic perfluoroaryl borane and an electron-rich silane is demonstrated. This has long been proposed as an intermediate in the ‘frustrated’ Lewis-pair hydrosilylation of C=C, C=O and C=N double bonds, but its existence has, so far, only been inferred from indirect experimental evidence.

See also: News and Views by Stephan


Switching on the fluorescence of 2-aminopurine by site-selective microhydration pp989 - 993

Simon Lobsiger, Susan Blaser, Rajeev K. Sinha, Hans-Martin Frey & Samuel Leutwyler

doi:10.1038/nchem.2086

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The adenine analogue 2-aminopurine has been considered as intrinsically fluorescent and is widely used in biochemical assays to probe DNA and RNA structure. It is now shown that the molecule alone is nearly non-fluorescent, however, its fluorescence is increased by up to 95 times through hydrogen bonding to a single water molecule.


DNA brick crystals with prescribed depths pp994 - 1002

Yonggang Ke, Luvena L. Ong, Wei Sun, Jie Song, Mingdong Dong, William M. Shih & Peng Yin

doi:10.1038/nchem.2083

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The programmed assembly of single DNA strands into bricks and ultimately micrometre-sized two-dimensional crystals with prescribed depths up to 80 nm is described. These crystals display intricate three-dimensional features including continuous or discontinuous cavities and channels with nanometre precision, and can pack DNA helices in parallel or perpendicularly to the plane of the crystals.


Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors pp1003 - 1008

Kyung-Ae Yang, Mihaela Barbu, Marlin Halim, Payal Pallavi, Benjamin Kim, Dmitry M. Kolpashchikov, Stevan Pecic, Steven Taylor, Tilla S. Worgall & Milan N. Stojanovic

doi:10.1038/nchem.2058

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Recognition, differentiation and sensing of small molecules displaying only sparse functionalities using artificial receptors is extremely challenging. Now a method to selectively bind and recognise low-epitope targets has been developed. The approach uses the formation of ternary complexes between small-molecule targets, their non-specific organic (or organometallic) receptors, and aptamers.


Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides pp1009 - 1016

Shiyu Chen, Ranganath Gopalakrishnan, Tifany Schaer, Fabrice Marger, Ruud Hovius, Daniel Bertrand, Florence Pojer & Christian Heinis

doi:10.1038/nchem.2043

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Disulfide bonds formed between two cysteine residues are important in the folding and stability of proteins. Now, unnatural amino acids with side-chains that contain two thiol groups are described. Incorporation of these dithiol amino acids into a serine protease inhibitor and a nicotinic acetyl choline receptor antagonist is shown to increase their inhibitory activity.


Dynamic covalent chemistry of bisimines at the solid/liquid interface monitored by scanning tunnelling microscopy pp1017 - 1023

Artur Ciesielski, Mohamed El Garah, Sébastien Haar, Petr Kovaříček, Jean-Marie Lehn & Paolo Samorì

doi:10.1038/nchem.2057

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Constructing molecular architectures using dynamic covalent chemistry combines the robustness of covalent bonds with the reversibility of supramolecular chemistry. Now, a surface-mediated approach has been used to control the thermodynamic and kinetic features of dynamic processes at a surface, leading to constituent selection and selective pattern formation.


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Corrigendum

Control and induction of surface-confined homochiral porous molecular networks p1024

Kazukuni Tahara, Hiroyuki Yamaga, Elke Ghijsens, Koji Inukai, Jinne Adisoejoso, Matthew O. Blunt, Steven De Feyter & Yoshito Tobe

doi:10.1038/nchem.2098


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In Your Element

Unsporting scandium p1025

John Emsley

doi:10.1038/nchem.2090

From Earth to the stars and back again, John Emsley surveys the uses, occurrences and mysteries of an element that is playing an increasing role in human affairs.


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Addenda

In Your Element: Manganese the protector p1026

John Emsley

doi:10.1038/nchem.2096


In Your Element: The A–Z of zirconium p1026

John Emsley

doi:10.1038/nchem.2097


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