The interactions between ruthenium complexes and DNA duplexes, elucidated in detail in three different crystal structures, have been found to occur through the minor groove — an unexpected binding mode, but perhaps not such a strange one.
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Neidle, S. Into the minor groove. Nature Chem 4, 594–595 (2012). https://doi.org/10.1038/nchem.1413
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DOI: https://doi.org/10.1038/nchem.1413
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