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Relieving PEGylation

Nature Chemistry volume 4, pages 13–14 (2012)Cite this article

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A new type of protein–polymer conjugate provides improved stability without detrimentally affecting bioactivity, and thus offers great potential for the development of new peptide-based drugs.

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Figure 1: The effect of polymer conjugation on peptide therapeutics.

ENZYME: ©ISTOCKPHOTO.COM/MARTIN MCCARTHY

References

  1. Leader, B., Baca, Q. J. & Golan, D. E. Nature Rev. Drug Discov. 7, 21–39 (2008).

    Article  CAS  Google Scholar 

  2. Wild, S., Roglic, G., Green, A., Sicree, R. & King, H. Diabetes Care 27, 1047–1053 (2004).

    Google Scholar 

  3. Veronese, F. M. & Pasut, G. Drug Discov. Today 10, 1451–1458 (2005).

    Article  CAS  Google Scholar 

  4. Veronese, F. M & Mero, A. Biodrugs 22, 315–329 (2008).

    Article  CAS  Google Scholar 

  5. Bailon, P. et al. Bioconjugate Chem. 12, 195–202 (2001).

    Article  CAS  Google Scholar 

  6. Keefe, A. J. & Jiang, S. Nature Chem. 4, 59–63 (2012).

    Article  CAS  Google Scholar 

  7. Yang, W., Zhang, L., Wang, S., White, A. D. & Jiang, S. Biomaterials 30, 5617–5621 (2009).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Matthew Parrott and Joseph DeSimone are in the Department of Chemistry at the University of North Carolina at Chapel Hill, CB# 3290, 257 Caudill, Chapel Hill, North Carolina 27599-3290, USA,

    Matthew C. Parrott & Joseph M. DeSimone

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  1. Matthew C. Parrott
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  2. Joseph M. DeSimone
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Correspondence to Joseph M. DeSimone.

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Parrott, M., DeSimone, J. Relieving PEGylation. Nature Chem 4, 13–14 (2012). https://doi.org/10.1038/nchem.1230

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