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Biophysics

Breaking out of the cage

Activating caged reactive sites in proteins using mechanical force provides a powerful approach in the study of chemical reactions, and provides greater insight into which reactions are possible and their rates.

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Figure 1: Reactions of caged disulfide (DS) bonds assessed through a nanomechanical approach, and potential applications in a microfluidic device.

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Correspondence to Markus J. Buehler.

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Chou, CC., Buehler, M. Breaking out of the cage. Nature Chem 3, 837–839 (2011). https://doi.org/10.1038/nchem.1182

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