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Mechanochemistry

Tearing apart triazoles

Nature Chemistry volume 3, pages 834–835 (2011)Cite this article

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An Addendum to this article was published on 22 April 2015

This article has been updated

Science 333, 1606–1609 (2011)

The copper-catalysed cycloaddition between an azide and an alkyne to form a five-membered triazole ring is perhaps the most well-known — and well-used — example of so-called click chemistry. The reaction is typically fast, occurs under mild conditions, exhibits a very high level of chemoselectivity and produces stable products. These characteristics have led to this particular reaction being used for many different applications, ranging from the labelling of biological macromolecules through to the patterning of surfaces.

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Change history

  • 25 March 2015

    The Science article on which this Research Highlight is based was retracted (Editorial retraction. Science 347, 834; 2015) on 20 February 2015 after an investigation at The University of Texas at Austin found that the data and conclusions reported in the study are unreliable.

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  1. Stuart Cantrill
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Cantrill, S. Tearing apart triazoles. Nature Chem 3, 834–835 (2011). https://doi.org/10.1038/nchem.1188

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