Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Amyloid formation

Interface influence

The aggregation of proteins into fibrils plays a crucial role in neurological conditions such as Parkinson's disease. Further insight into fibril formation has now been gained that reveals the effect of hydrophobic surfaces, including air.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Formation of amyloid fibrils of protein α-synuclein.

References

  1. Chiti, F. & Dobson, C. M. Annu. Rev. Biochem. 75, 333–366 (2006).

    Article  CAS  Google Scholar 

  2. Hamley, I. W. Angew. Chem. Int. Ed. 46, 8128–8147 (2007).

    Article  CAS  Google Scholar 

  3. Knowles, T. P. J. et al. Science 326, 1533–1537 (2009).

    Article  CAS  Google Scholar 

  4. Pronchik, J., He, X., Giurleo, J. T. & Talaga, D. S. J. Am. Chem. Soc. 132, 9797–9803 (2010).

    Article  CAS  Google Scholar 

  5. Cabaleiro-Lago, C., Lynch, I., Dawson, K. A. & Linse, S. Langmuir 26, 3453–3461 (2010).

    Article  CAS  Google Scholar 

  6. Chromy, B. A. et al. Biochemistry 42, 12749–12760 (2003).

    Article  CAS  Google Scholar 

  7. Soreghan, B., Kosmoski, J. & Glabe, C. G. J. Biol. Chem. 269, 28551–28554 (1994).

    CAS  PubMed  Google Scholar 

  8. Kim, W. K. & Hecht, M. H. Proc. Natl Acad. Sci. USA 103, 15824–15829 (2006).

    Article  CAS  Google Scholar 

  9. Petkova, A. T. et al. Science 307, 262–265 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hamley, I. Interface influence. Nature Chem 2, 707–708 (2010). https://doi.org/10.1038/nchem.816

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.816

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing