Monitoring the dynamics of a single molecule is impeded by their motion in solution, and immobilizing them without changing their properties is problematic. By using a trapping method that counteracts a molecule's Brownian motion, the complex dynamics of a fluorescent protein, allophycocyanin, have been investigated.
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Dedecker, P., Hofkens, J. Caught in a trap. Nature Chem 2, 157–159 (2010). https://doi.org/10.1038/nchem.562
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DOI: https://doi.org/10.1038/nchem.562
