News and Views
Nature Chemistry 1, 596 - 597 (2009)
doi:10.1038/nchem.427
Subject Categories: Medicinal chemistry | Theoretical chemistry
Protein–protein interactions: Making drug design second nature
-
Dan Sackett is in the Laboratory of Integrative and Medical Biophysics, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 9 Memorial Drive, Bethesda Maryland 20892-0924, USA.
e-mail: sackettd@mail.nih.gov -
David Sept is in the Department of Biomedical Engineering and the Center for Computational Medicine and Bioinformatics at the University of Michigan, 1101 Beal Ave, Ann Arbor, Michigan 4810, USA.
e-mail: dsept@umich.edu
Abstract
Identifying inhibitors of protein–protein interactions is an ongoing challenge in the field of drug design, but the use of peptide fragments based on a known binding interface is showing promise.
