Exponential signal amplification is achieved when a single molecule of analyte initiates a chain reaction in which a dendrimer releases a coloured 'reporter' molecule, and ultimately four further molecules of the analyte.
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References
Hendrickson, E. R., Hatfield Truby, T. M., Joerger, R. D., Majarian, W. R. & Ebersole, R. C. Nucl. Acids Res. 23, 522–529 (1995).
Engvall, E., Jonsson, K. & Perlmann, P. Biochim. Biophys. Acta. 251, 427–434 (1971).
Sano, T., Smith, C. L. & Cantor, C. R. Science 258, 120–122 (1992).
Sella, E. & Shabat, D. J. Am. Chem. Soc. 131, 9934–9936 (2009).
Darbre, T. & Reymond, J.-L. Acc. Chem. Res. 39, 925–934 (2006).
Amir, R. J., Pessah, N., Shamis, M. & Shabat, D. Angew. Chem. Int. Ed. 42, 4494–4499 (2003).
Szalai, M. L., Kevwitch, R. M. & McGrath, D. V. J. Am. Chem. Soc. 125, 15688–15689 (2003).
de Groot, F. M. H., Albrecht, C., Koekkoek, R., Beusker, P. H. & Scheeren, H. W. Angew. Chem. Int. Ed. 42, 4490–4494 (2003).
Shamis, M., Lode, H. N. & Shabat, D. J. Am. Chem. Soc. 126, 1726–1731 (2004).
Sella, E. & Shabat, D. Chem. Comm. 5701–5703 (2008).
Zhu, L. & Anslyn, E. V. Angew. Chem. Int. Ed. 45, 1190–1196 (2006).
Patzke, V. & von Kiedrowski, G. ARKIVOC 5, 293–310 (2007).
Soai, K., Shibata, T., Marioka, H. & Choji, K. Nature 378, 767–768 (1995).
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Swiderska, M., Reymond, JL. A dendritic signal amplifier. Nature Chem 1, 527–528 (2009). https://doi.org/10.1038/nchem.385
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DOI: https://doi.org/10.1038/nchem.385
