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Nature Chemistry 1, 257 - 258 (2009)
Published online: 14 June 2009 | doi:10.1038/nchem.264
Subject Categories: Analytical chemistry | Biochemistry
Bioanalytical chemistry: Protein oligomers frozen in time
David E. Clemmer1 & Stephen J. Valentine1
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David E. Clemmer and Stephen J. Valentine are in the Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
e-mail: clemmer@indiana.edu
Abstract
The size and shape of amyloid-
protein assemblies have been studied using electrospray-ionization ion-mobility mass spectrometry, and the protein tetramers and dodecamers have been identified as an important oligomerization state in the development of neurodegenerative disease.
