Focuses


2017

Membrane Transport

Membrane transport

Extracellular chemical signals that mediate a range of intracellular functions must either be directly transported across cell membranes or be bound to a receptor causing a response to be propagated into the cell interior. A variety of systems have evolved that can operate in this way, but designing synthetic systems that replicate such functions is not trivial. A collection of articles in this Focus discuss artificial methods for transporting chemical information across a lipid bilayer.

Origins of life

Origins of life

The question of what chemical and physical processes combined to produce the first living systems is perhaps impossible to answer with any certainty, but research continues to provide clues that may help us understand our primordial past. A collection of articles in this Focus explore the origins of RNA and its role in contemporary biological systems, revealing new insights into what early Earth might have looked like and how life first emerged.

2016

Protein metal–nitrosyl motifs

Protein metal–nitrosyl motifs

Nitric oxide (NO) is an important signalling molecule involved in a variety of biological processes, but the way in which it interacts with some metalloproteins is not well understood. A collection of articles in this issue reveals how NO binds to proteins containing type-1 copper sites, based on studies with small-molecule mimics and engineered model proteins.

Developing chemistry

Developing chemistry

Improving the practice of chemistry research and education in the developing world would enable global challenges — such as the need for water and food security, better health, and cleaner energy — to be tackled more effectively by those who are more directly affected by these issues. A collection of articles in this Focus highlight some of the problems faced by researchers in less-developed countries and describe a variety of ways in which local resources can be used in establishing self-sustained research communities that can contribute to chemistry on an international scale.

Site-specific modification of proteins

Site-specific modification of proteins

Homogenous protein conjugates are required for many biological and therapeutic applications. A collection of articles in this Focus highlights some of the latest advances in developing new site-selective reactions for modifying proteins.

2015

Molecular Electronics

Molecular electronics

The miniaturization of electronic devices that use silicon-based technology will soon reach a limit and if devices are to continue getting smaller, scientists must harness the electronic properties of single molecules. A collection of Articles in this Focus highlights recent progress in the understanding and control of charge transport through single molecules.

2014

Site-selective reactions

Biomimetic drug discovery

Natural products and their derivatives have long been a significant source of pharmaceuticals. A collection of articles in this Focus highlights efforts to mimic some aspects of the way in which these compounds are made in nature with the aim of improving the processes by which synthetic drug leads are identified.

Site-selective reactions

2D polymers

The properties of 2D materials, such as graphene, arise not only from their composition but also their sheet-like structures. Synthetic 2D polymers made from well-defined monomers promise to expand the range of such materials, but are very difficult to synthesize. A collection of articles in this Focus highlights some of the latest research in making and characterizing single-crystal synthetic 2D polymers, and also considers the challenges and potential for these materials in the future.

Site-selective reactions

Five-year anniversary

Nature Chemistry is now five years old! To celebrate, we look at some facts and figures relating to the manuscripts that have passed through our hands — including information about how many submissions we have received and where they came from, our referee pool, the authors and titles of published papers, as well as some citation data. Each editor has also picked out one of their favourite papers and explains why it stood out for them.

2013

Site-selective reactions

Prebiotic chemistry

Understanding how the simple molecules present on the early Earth may have given rise to the complex systems and processes of contemporary biology is widely regarded as one of chemistry's great unsolved questions. A collection of articles in this focus highlight some of the latest research in this area, including work that supports the RNA-world hypothesis.

2012

Site-selective reactions

Site-selective reactions

Reaction methodologies that can selectively target one reactive site among many that are functionally similar within a complex molecule could significantly improve synthetic efficiency and help in the identification of new drug leads. A collection of articles in this focus highlight some of the latest advances in this area, explaining the complementary approaches taken by researchers to this challenge.

Small DNA binders

Small DNA binders

Photosensitive metal complexes that are able to bind to DNA duplexes hold promise for diagnostic and therapeutic applications — but the precise details of how they interact with DNA need to be better understood. A collection of articles in this focus highlight some of the latest advances in elucidating their binding modes as well as challenges associated with this area of research.

Protein Dynamics

Protein dynamics

The past decade has seen a debate grow on the possibility that the motions of enzymes could influence the contribution that quantum mechanical tunnelling makes to their activity. In this focus we highlight differing views on the significance that structural dynamics has on the reactivity of enzymes.

2010

First-anniversary highlights

First-anniversary highlights

April 2010 marks the first anniversary of the launch of Nature Chemistry. To celebrate, we have put together a compilation of our favourite articles from the first 12 issues. The selection, which is free until the end of June 2010, reflects the breadth of topics covered by Nature Chemistry. We hope you enjoy it.

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