How to submit

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Online submission

Owing to the volume of manuscripts we receive, we must insist that all submissions be made via our online submission system. Using this system, authors can upload manuscript files (text, figures and supplementary information, including video) directly to our office and check on the status of their manuscripts during the review process. In addition, reviewers can access the manuscript (in a highly secure fashion that maintains referee anonymity) over a direct internet link, which speeds up the review process. Please consult our technical information on file formats and tips for using the system effectively. Revised manuscripts should be uploaded via the link provided in the editor's decision letter. Please do not submit revisions as new manuscripts.

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Submission policies

Submission to Nature Chemistry is taken to imply that there is no significant overlap between the submitted manuscript and any other papers from the same authors under consideration or in press elsewhere. (Abstracts or unrefereed web preprints do not compromise novelty). The authors must include copies of all related manuscripts with any overlap in authorship that are under consideration or in press elsewhere. If a related manuscript is submitted elsewhere while the manuscript is under consideration at Nature Chemistry, a copy of the related manuscript must be sent to the editor.

Submission is also taken to imply that all co-authors have approved the contents of the manuscript and its submission by the corresponding author, and that the corresponding author is authorized to represent all co-authors in pre-publication discussions with the journal. The corresponding author for editorial purposes need not be the senior author or the person to whom correspondence is addressed after publication. The primary affiliation for each author should be the institution where the majority of the work was done. If an author has subsequently moved, the current address may also be stated. Statements of equal contribution from more than one author are permitted.

If the manuscript includes personal communications, please provide a written statement of permission from any person who is quoted. E-mail permission messages are acceptable.

Follow this link for further information on the review process and how editors make decisions.

A high priority of Nature Chemistry is that all papers be accessible to non-specialists. Manuscripts are subject to substantial editing, in consultation with the authors, to achieve this goal. After acceptance, a copy editor may make further changes so that the text and figures are readable and clear to those outside the field, and so that papers conform to our style. Contributors are sent proofs and are welcome to discuss proposed changes with the editors, but Nature Chemistry reserves the right to make the final decision about matters of style and the size of figures.

The editors also reserve the right to reject a paper even after it has been accepted if it becomes apparent that there are serious problems with the scientific content or with violations of our publishing policies.

Additional editorial policies can be found on the Nature journals joint policies page. This page includes information on manuscripts reviewed at other Nature journals, competing financial interests declarations, pre-publication publicity, deposition of data as a condition of publication, availability of data and reagents after publication, human and animal subjects, digital image integrity, biosecurity, refutations, complaints, correction of mistakes, duplicate publication, confidentiality and plagiarism.

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Costs

There is a charge of $500 for the first colour figure and $250 for each additional colour figure. Please note that we are unable to offer to publish greyscale in print and colour online. Otherwise, there are no submission fees or page charges.

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Advance online publication

Nature Chemistry provides Advance Online Publication (AOP) of research articles, which benefits authors with an earlier publication date and enables our readers to access accepted papers before they appear in print. Note that papers published online are definitive and may be altered only through the publication of a corrigendum or erratum, so authors should make every effort to ensure that the page proofs are correct. All AOP articles are given a unique digital object identifier (DOI) number, which can be used to cite the paper before print publication. Follow this link for details about advance online publication.

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General information for preparing manuscripts

Manuscripts should be prepared for online submission. Online submissions include a cover letter, a manuscript text file, individual figure files and optional Supplementary Information files. For first submissions (i.e. not revised manuscripts), authors may choose to incorporate the manuscript text and figures into a single file (Microsoft Word, TeX/LaTeX or PDF) up to 3 MB in size — the figures may be inserted within the text at the appropriate positions, or grouped at the end. Supplementary Information should be combined and supplied as a separate file, preferably in PDF format.

Nature Chemistry is read by scientists from diverse backgrounds. In addition, many are not native English speakers. Authors should, therefore, give careful thought to how their findings may be communicated clearly. Although a shared basic knowledge of chemistry may be assumed, please bear in mind that the language and concepts that are standard in one subfield may be unfamiliar to non-specialists. Thus, technical jargon should be avoided as far as possible and clearly explained where its use is unavoidable.

Abbreviations, particularly those that are not standard, should also be kept to a minimum. Chemical abbreviations should be defined in the text or legends at their first occurrence, and abbreviations should be used thereafter. The background, rationale and main conclusions of the study should be clearly explained. Titles and abstracts in particular should be written in language that will be readily intelligible to any scientist. We strongly recommend that authors ask a colleague with different expertise to review the manuscript before submission, in order to identify concepts and terminology that may present difficulties to non-specialist readers.

Follow this link for information about the different types of contributions, along with their length and figure limits. The journal's format requirements are described below.

Nature Chemistry uses Oxford English spelling.

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Cover Letter

Authors should provide a cover letter that includes the affiliation and contact information for the corresponding author. Authors should briefly discuss the work's importance and explain why the work is considered appropriate for the diverse readership of Nature Chemistry. Authors are asked to provide the names and contact information for qualified scientific reviewers and they may request the exclusion of certain referees. Finally, authors should indicate whether they have had any prior discussions with a Nature Chemistry editor about the work described in the manuscript.

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Graphical abstract

A graphical abstract, which summarizes the manuscript in a visual way, is designed to attract the attention of readers in the table of contents of the journal. Graphical abstracts are published with Articles, Reviews and Perspectives. The graphical abstract may contain chemical structures or images. Textual statements should be kept to a minimum. Colour graphical abstracts are encouraged and will be published at no additional charge. The image must be sized to fit in a rectangle of dimensions 90 mm wide × 40 mm high. The graphic should be submitted as a single file using a standard file format (see below) and will be published in the table of contents in print and online. All graphical abstracts should be submitted with a white background and imagery should fill the available width, whenever possible. Please see figure guidelines for resolution requirements.

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Manuscript text

For first submissions (i.e. not revised manuscripts), authors may choose to incorporate the manuscript text and figures into a single file (Microsoft Word, TeX/LaTeX or PDF) up to 3 MB in size — the figures may be inserted within the text at the appropriate positions, or grouped at the end. Supplementary Information should be combined and supplied as a separate file, preferably in PDF format. Where possible the first page of each Supplementary Information file should include the title of the manuscript and the author list.

Alternatively authors can follow the guidelines outlined below, which must be followed when submitting files for revisions.

All textual content should be provided in a single file, prepared using either Microsoft Word or TeX/LaTeX; figures should be provided in individual files. The manuscript text file should include the following parts, in order: a title page with author affiliations and contact information (the corresponding author should be identified with an asterisk); the sections required for each content type (see information for different content types) then References, Acknowledgements (optional), Author Contributions (optional), Competing Financial Interests statement, Figure Legends and Tables.

Microsoft Word — Nature Chemistry does not use a manuscript template for Word documents. The manuscript file should be formatted as double-spaced, single-column text without justification. Pages should be numbered using an Arabic numeral in the footer of each page. Standard fonts are recommended and the 'symbols' font should be used for representing Greek characters.

TeX/LaTeX — Authors submitting LaTeX files may use any of the standard class files such as article.cls, revtex.cls or amsart.cls. Non-standard fonts should be avoided; please use the default Computer Modern fonts. For the inclusion of graphics, we recommend graphicx.sty. Please use numerical references only for citations. There is no need to spend time visually formatting the manuscript: Nature Chemistry style will be imposed when the paper is prepared for publication. References should be included within the manuscript file itself as our system cannot accept BibTeX bibliography files. Authors who wish to use BibTeX to prepare their references should therefore copy the reference list from the .bbl file that BibTeX generates and paste it into the main manuscript .tex file (and delete the associated \bibliography and \bibliographystyle commands). As a final precaution, authors should ensure that the complete .tex file compiles successfully on their own system with no errors or warnings, before submission.

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Chemical nomenclature and abbreviations

Molecular structures are identified by bold, Arabic numerals assigned in order of presentation in the text. Once identified in the main text or a figure, compounds may be referred to by their name, by a defined abbreviation, or by the bold Arabic numeral (as long as the compound is referred to consistently as one of these three).

When possible, authors should refer to chemical compounds and biomolecules using systematic nomenclature, preferably using IUPAC. Standard chemical and biological abbreviations should be used. Unconventional or specialist abbreviations should be defined at their first occurrence in the text.

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Methods

Authors must ensure that their manuscripts include adequate experimental and characterization data necessary for others in the field to reproduce their work. The Methods section in the main text is limited to 800 words and should include those methods considered to be the most essential to the paper. Additional methods, experimental procedures and characterization data should be placed in the Supplementary Information, which will be made available to referees during the peer-review process.

1. General methods

Descriptions of standard protocols and experimental procedures should appear in Supplementary Information. Commercial suppliers of reagents or instrumentation should be identified only when the source is critical to the outcome of the experiments. Sources for kits should be identified in the Methods section or Supplementary Information.

2. Synthetic protocols

Experimental protocols that describe the synthesis of new compounds should be included. The systematic name of the compound and its bold Arabic numeral are used as the heading for the experimental protocol. Thereafter, the compound is represented by its assigned bold numeral. Authors should describe the experimental protocol in detail, referring to amounts of reagents in parentheses, when possible (e.g. 1.03 g, 0.100 mmol). Standard abbreviations for reagents and solvents are encouraged. Safety hazards posed by reagents or protocols should be identified clearly. Isolated mass and percent yields should be reported at the end of each protocol.

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Characterization of chemical and biomolecular materials

Nature Chemistry is committed to publishing the highest-quality research. Manuscripts submitted to the journal will be held to rigorous standards with respect to experimental methods and characterization of new compounds. Authors must provide adequate data to support their assignment of identity and purity for each new compound described in the manuscript. Authors should provide a statement confirming the source, identity and purity of known compounds that are central to the scientific study, even if they are purchased or resynthesized using published methods.

1. Chemical identity

Chemical identity for organic and organometallic compounds should be established through spectroscopic analysis. Standard peak listings (see formatting guidelines below) for 1H NMR and proton-decoupled 13C NMR should be provided for all new compounds. Other NMR data should be reported (31P NMR, 19F NMR, etc.) when appropriate. For new materials, authors should also provide mass spectral data to support molecular weight identity. High-resolution mass spectral (HRMS) data are preferred. UV or IR spectral data may be reported for the identification of characteristic functional groups, when appropriate. Melting-point ranges should be provided for crystalline materials. Specific rotations may be reported for chiral compounds. Authors should provide references, rather than detailed procedures, for known compounds, unless their protocols represent a departure from or improvement on published methods.

2. Combinatorial compound libraries

Authors describing the preparation of combinatorial libraries should include standard characterization data for a diverse panel of library components.

3. Biomolecular identity

For new biopolymeric materials (oligosaccharides, peptides, nucleic acids, etc.), direct structural analysis by NMR spectroscopic methods may not be possible. In these cases, authors must provide evidence of identity based on sequence (when appropriate) and mass spectral characterization.

4. Biological constructs

Authors should provide sequencing or functional data that validates the identity of their biological constructs (plasmids, fusion proteins, site-directed mutants, etc.) either in the manuscript text or the Methods section, as appropriate.

5. Sample purity

Evidence of sample purity is requested for each new compound. Methods for purity analysis depend on the compound class. For most organic and organometallic compounds, purity may be demonstrated by high-field 1H NMR or 13C NMR data, although elemental analysis (&plusmin;0.4%) is encouraged for small molecules. Quantitative analytical methods including chromatographic (GC, HPLC, etc.) or electrophoretic analyses may be used to demonstrate purity for small molecules and polymeric materials.

6. Spectral data

Detailed spectral data for new compounds should be provided in list form (see below) in the Methods section or Supplementary Methods. Figures containing spectra generally will not be published as a manuscript figure unless the data are directly relevant to the central conclusions of the paper. Authors are encouraged to include high-quality images of spectral data for key compounds in the Supplementary Information. Specific NMR assignments should be listed after integration values only if they were unambiguously determined by multidimensional NMR or decoupling experiments. Authors should provide information about how assignments were made in a general Methods section.

Example format for compound characterization data. mp: 100–102 °C (lit.ref 99–101 °C); TLC (CHCl3:MeOH, 98:2 v/v): Rf = 0.23; [α]D = -21.5 (0.1 M in n-hexane); 1H NMR (400 MHz, CDCl3): δ 9.30 (s, 1H), 7.55–7.41 (m, 6H), 5.61 (d, J = 5.5 Hz, 1H), 5.40 (d, J = 5.5 Hz, 1H), 4.93 (m, 1 H), 4.20 (q, J = 8.5 Hz, 2H), 2.11 (s, 3H), 1.25 (t, J = 8.5 Hz, 3H); 13C NMR (125 MHz, CDCl3): δ 165.4, 165.0, 140.5, 138.7, 131.5, 129.2, 118.6, 84.2, 75.8, 66.7, 37.9, 20.1; IR (Nujol): 1765 cm-1; UV/Vis: λmax 267 nm; HRMS (m/z): [M]+ calcd. for C20H15Cl2NO5, 420.0406; found, 420.0412; analysis (calcd., found for C20H15Cl2NO5): C (57.16, 57.22), H (3.60, 3.61), Cl (16.87, 16.88), N (3.33, 3.33), O (19.04, 19.09).

7. Crystallographic data for small molecules

Manuscripts reporting new three-dimensional structures of small molecules from crystallographic analysis should include a .cif file and a structural figure with probability ellipsoids. Crystallographic data for small molecules should be submitted upon publication to the Cambridge Structural Database.

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References

References should be numbered sequentially first throughout the text, then in tables, followed by figures and, finally, boxes; that is, references that only appear in tables, figures or boxes should be last in the reference list. Only one publication is given for each number. Only papers that have been published or accepted by a named publication or recognized preprint server should be in the numbered list; preprints of accepted papers in the reference list should be submitted with the manuscript. Published conference abstracts and numbered patents may be included in the reference list. Grant details and acknowledgments are not permitted as numbered references. Footnotes are not used.

BibTeX bibliography files cannot be accepted. LaTeX submission must contain all references within the manuscript .tex file itself (see above TeX/LaTeX section for more details).

Nature Chemistry uses standard Nature referencing style. All authors should be included in reference lists unless there are six or more, in which case only the first author should be given, followed by 'et al.'. Authors should be listed last name first, followed by a comma and initials (followed by full stops) of given names. Article titles should be in Roman text, only the first word of the title should have an initial capital and the title should be written exactly as it appears in the work cited, ending with a full stop. Book titles should be given in italics and all words in the title should have initial capitals. Journal names are italicized and abbreviated (with full stops) according to common usage. Volume numbers and the subsequent comma appear in bold. The full page range should be given, where appropriate.

Titles of cited articles are required for Articles, Perspectives and Reviews. Example: Baran, P. S., Maimone, T. J. & Richter, J. M. Total synthesis of marine natural products without using protecting groups. Nature 446, 404–408 (2007).

For Commentaries and News & Views articles, titles of cited articles are not included. Example: Xu, P. et al. Nature 431, 1107–1112 (2004).

For book citations, the publisher and city of publication are required. Example: Eliel, E. L. & Wilen, S. H. Stereochemistry of Organic Compounds Ch. 12 (Wiley, New York, 1994).

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Acknowledgements

Acknowledgements should be brief, and should not include thanks to anonymous referees and editors, or effusive comments. Grant or contribution numbers may be acknowledged.

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Author contributions

Nature Chemistry encourages authors to include a statement to specify the individual contributions of each co-author. Please note that, despite this declaration, the corresponding author must certify that all authors have agreed to all the content in the manuscript, including the data as presented.

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Competing financial interests

A competing financial interests statement is required for all content of the journal, but will be published only if any competing financial interests are reported.

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Figure legends

Figure legends begin with a brief title sentence for the whole figure and continue with a short description of what is shown in each panel and the symbols used; methodological details should be kept to a minimum as much as possible. Each legend should total no more than 200 words. Text for figure legends should be provided in numerical order after the references.

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Tables

Please submit tables at the end of your text document (in Word or TeX/LaTeX, as appropriate). Tables that include statistical analysis of data should describe their standards of error analysis and ranges in a table legend.

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Equations

Equations and mathematical expressions should be provided in the main text of the paper. Equations that are referred to in the text are identified by parenthetical numbers, such as (1), and are referred to in the manuscript as "equation (1)".

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General figure guidelines

Authors are responsible for obtaining permission to publish any figures or illustrations that are protected by copyright, including figures published elsewhere and pictures taken by professional photographers. The journal cannot publish images downloaded from the internet without appropriate permission.

Figures should be numbered separately with Arabic numerals in the order of occurrence in the text of the manuscript. One- or two-column format figures are preferred. When appropriate, figures should include error bars. A description of the statistical treatment of error analysis should be included in the figure legend. Please note that schemes are not used; sequences of chemical reactions or experimental procedures should be submitted as figures, with appropriate captions. A limited number of uncaptioned graphics depicting chemical structures — each labelled with their name, by a defined abbreviation, or by the bold Arabic numeral — may be included in a manuscript. Although suggestions can be made by the authors, the final decision regarding the positioning and grouping of such structures rests with the editorial team.

Figure lettering should be in a clear, sans-serif typeface (for example, Helvetica); if possible, the same typeface in approximately the same font size should be used for all figures in a paper. Use symbol font for Greek letters. All display items should be on a white background, and should avoid excessive boxing, unnecessary colour, spurious decorative effects (such as three-dimensional 'skyscraper' histograms) and highly pixelated computer drawings. The vertical axis of histograms should not be truncated to exaggerate small differences. Labelling must be of sufficient size and contrast to be readable, even after appropriate reduction. The thinnest lines in the final figure should be no smaller than one point wide. Reasonable requests to enlarge figures will be considered, but editors will make the final decision on figure size. Authors will see a proof of figures.

Figures divided into parts should be labelled with a lower-case bold a, b, and so on, in the same type size as used elsewhere in the figure. Lettering in figures should be in lower-case type, with only the first letter of each label capitalized. Units should have a single space between the number and the unit, and follow SI nomenclature (for example, ms rather than msec) or the nomenclature common to a particular field. Thousands should be separated by commas (1,000). Unusual units or abbreviations should be spelled out in full or defined in the legend. Scale bars should be used rather than magnification factors, with the length of the bar defined on the bar itself rather than in the legend. In legends, please use visual cues rather than verbal explanations such as "open red triangles".

Unnecessary figures should be avoided: data presented in small tables or histograms, for instance, can generally be stated briefly in the text instead. Figures should not contain more than one panel unless the parts are logically connected; each panel of a multipart figure should be sized so that the whole figure can be reduced by the same amount and reproduced on the printed page at the smallest size at which essential details are visible.

When a manuscript is accepted for publication, we will ask for high-resolution figure files, possibly in a different electronic format. This information will be included in the acceptance letter. See below for details of digital image production and submission.

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Figures for peer review

Figures should be uploaded on submission via our online submission system, in one of our preferred formats, if possible. Please use the smallest file size that provides sufficient resolution for their content to be clearly legible, preferably less than 1 MB, so that referees do not have to download extremely large files.High-resolution images are not required at initial submission. When a paper is accepted, the editors will request high-resolution files suitable for publication.

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Figures for publication

Please read the digital images integrity and standards policy. When possible, we prefer to use original digital figures to ensure the highest-quality reproduction in the journal. For optimal results, prepare figures at actual size for the printed journal. When creating and submitting digital files, please follow the guidelines below. Failure to do so, or to adhere to the following guidelines, can significantly delay publication of your work.

Authors are responsible for obtaining permission to publish any figures or illustrations that are protected by copyright, including figures published elsewhere and pictures taken by professional photographers. The journal cannot publish images downloaded from the internet without appropriate permission.

1. Line art, graphs, charts and schematics

All line art, graphs, charts and schematics should be supplied in vector format, such as Encapsulated PostScript (.EPS), Adobe Illustrator (.AI), or Portable Document Format (.PDF), and should be saved or exported as such directly from the application in which they were made. This allows us to restyle to our journal house style.

We prefer to work with Adobe Illustrator but can accept Word and PowerPoint files.

They should not be flattened, compressed, converted or saved as bitmaps, jpegs or other non-vector file types. If line-art figures cannot be supplied as vector files they should be supplied at 1,200 DPI and as close to print size as possible.

2. Photographic and bitmapped images

All photographic and bitmapped images should be supplied in TIFF format at a minimum of 300 DPI and as close to print size as possible. For final print size please use our column widths as a guide. A single column width measures 88 mm and a double column width measures 170 mm. In practice this means that the absolute width of single-column figures should be no less than 1,040 pixels wide and double-column figures should be no less than 2,080 pixels wide (excluding peripheral white space).

We can accept Word and PowerPoint files but please supply any placed images as separate tiffs, prepared as above. If preparing in Adobe Photoshop please type all text on separate text layers so that we can retype in our own house style. If this is not possible please supply two sets of figures - one with labelling for our reference, and one without labelling. Please make sure any scale bars or important markers are left on both sets.

Where possible please supply colour photographic images in CMYK colour mode as colour detail may be lost converting from RGB to CMYK.

Please do not scan laser printouts of figures and send them to us as digital files. The dot pattern on a laser print often creates a moiré pattern when scanned.

Figures that do not meet these standards will not reproduce well and may delay publication until we receive high-resolution images. We cannot be held responsible for assuming the cost of corrected reprints should poor-quality images need to be used.

3. Chemical structures

Chemical structures should be produced using ChemDraw or a similar program. All chemical compounds must be assigned a bold, Arabic numeral in the order in which the compounds are presented in the manuscript text. Figures containing chemical structures should be submitted in a size appropriate for direct incorporation into the printed journal. Authors using ChemDraw should make use of our journal template or use the preferences below, submitting the final files at 100% as .cdx files. Creating molecules within or copying them into the template will ensure that most of our journal style points are followed. For more information, please also review our Chemical Style Guide.

Drawing settings: chain angle, 120° bond spacing, 18% of width; fixed length, 14.4 pt; bold width, 2.0 pt; line width, 0.6 pt; margin width 1.6 pt; hash spacing 2.5 pt.

Atom Label settings: font, Arial; size, 8 pt. "Show labels on Terminal Carbons" and "Hide Implicit Hydrogens" should be unchecked.

4. Stereo images

Stereo diagrams should be presented for divergent 'wall-eyed' viewing, with the two panels separated by ∼5.5 cm. In the final accepted version of the manuscript, the stereo images should be submitted at their final print size.

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Cover and other artwork

Authors of accepted papers are encouraged to submit images for consideration as a cover. Cover images are normally linked to a specific paper in that issue. We may also be able to use other images elsewhere in the journal, such as on the table of contents. Illustrations are selected for their scientific interest and aesthetic appeal. Please send prints or electronic files (rather than slides) in the first instance. Please also include a clear and concise legend explaining the image.

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Supplementary Information

Supplementary Information should be submitted with the manuscript and will be sent to referees during peer review. It is published with the online version of accepted manuscripts. We request that authors avoid "data not shown" statements and instead include data necessary to evaluate the claims of the paper as Supplementary Information. Supplementary Information is not copy-edited by Nature Chemistry, so authors should ensure that it is clearly and succinctly presented, and that the style and terminology conform with the rest of the paper. Authors should include the title of the manuscript and full author list on the first page.

The submission of supplementary data sets relating to the characterization of chemical compounds is also encouraged, such as raw spectroscopic data from NMR, UV/Vis and IR experiments, and related techniques. Separate files should be submitted for each compound — at the present time, there is no preferred format and all types are welcome.

The guidelines below detail the creation, citation and submission of Supplementary Information — publication may be delayed if these are not followed correctly. Please note that modification of Supplementary Information after the paper is published requires a formal correction, so authors are encouraged to check their Supplementary Information carefully before submitting the final version.

1. Designate each item as Supplementary Table, Figure, Video, Audio, Note, Data, Discussion, Equations or Methods, as appropriate. Number Supplementary Tables and Figures as, for example, "Supplementary Table S1". This numbering should be separate from that used in tables and figures appearing in the main printed article. Supplementary Note or Methods should not be numbered; titles for these are optional.

2. Refer to each piece of supplementary material at the appropriate point(s) in the main article. Be sure to include the word "Supplementary" each time one is mentioned. Please do not refer to individual panels of supplementary figures.

3. Use the following examples as a guide (note: abbreviate "Figure" as "Fig." when in the middle of a sentence).

"Table 1 provides a selected subset of the most active compounds. The entire list of 96 compounds can be found as Supplementary Table S1 online."

"The biosynthetic pathway of L-ascorbic acid in animals involves intermediates of the D-glucuronic acid pathway (see Supplementary Fig. S2 online). Figure 2 shows..."

4. Audio and video files should use a frame size no larger than 320 × 240 pixels.

5. Images should be just large enough to view when the screen resolution is set to 640 × 480 pixels.

6. Remember to include a brief title and legend (incorporated into the file to appear near the image) as part of every figure submitted, and a title as part of every table.

7. File sizes should be as small as possible, with a maximum size of 3 MB, so that they can be downloaded quickly.

8. With the exception of spreadsheet, audio, video and compound characterization data files, please submit the Supplementary Information as a single combined PDF if possible. If necessary, we can also accept any of these formats:

.txt - Plain ASCII text
.gif - GIF image
.html - HTML document
.doc - MS Word document
.jpg - JPEG image
.swf - Flash movie
.xls - MS Excel spreadsheet
.pdf - Adobe Acrobat file
.mov - QuickTime movie
.ppt - MS Power Point slide
.wav - Audio file

Further queries about submission and preparation of Supplementary Information should be directed to email: nchem@nature.com.

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Deposition of chemical compound information to PubChem

For manuscripts that describe original research, the Nature Chemistry acceptance process includes automated deposition of the article's chemical compound data to PubChem by the Nature Chemistry staff. In the online version of the published paper, each chemical compound will be linked to a Compound Data Page, which includes links to PubChem and further information related to the compound. At the time of submission of the final revised version of the manuscript, authors should provide two files:

1. A single ChemDraw file (.cdx) that contains all of the structures in the manuscript that are identified with bold Arabic numerals (see Chemical Structure Display Items below). Reagents and solvents should not be included, and the structure of each compound should be 'grouped' with its assigned numeral. If the paper contains more chemical structures than will fit on a single page in ChemDraw, additional pages should be created within the same file.

2. A tab-delimited text (.txt) (or Microsoft Excel spreadsheet, .xls) file with two columns that associates the bold numeral of each compound included in the ChemDraw file with its IUPAC (or systematic) name. Widely recognized biochemical compounds and natural products may be referred to by their common names.

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