Research

This list contains the 50 most recently published research articles, including advance online publication articles that have not yet been published in a journal issue.

Showing: 1–25 of 50

AOP
  1. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor AOP

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    Wu et al. show that prosurvival BCL-2 proteins disrupt SUFU repression of GLI activity, leading to GLI target gene expression. BH3 mimetics disable GLI transcriptional activity driven by HH pathway mutations.

  2. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm AOP

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    Anderson et al. show that LIF, ActA and Wnt support self-renewal in both pluripotent and endodermal cells. Upon removal of insulin, they induce differentiation of naive PSCs into extra-embryonic primitive endoderm and primed PSCs into definitive endoderm.

  3. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS AOP

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    Wu et al. find that tumour hypoxic conditions increase miR25/93 levels, which via targeting Ncoa3 downregulate the expression of the innate immune regulator cGAS, thus allowing escape of the anti-tumour immune response.

  4. MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death AOP

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    Dondelinger et al. and Menon et al. show that MAPKAP kinase-2 (MK2) phosphorylates RIPK1 to regulate TNF-mediated cell death as well as RIPK1 signalling in inflammation and bacterial infection.

    See also: Article by Manoj B. Menon et al.

  5. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection AOP

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    Dondelinger et al. and Menon et al. show that MAPKAP kinase-2 (MK2) phosphorylates RIPK1 to regulate TNF-mediated cell death as well as RIPK1 signalling in inflammation and bacterial infection.

    See also: Article by Yves Dondelinger et al.

  6. Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny AOP

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    Ganuza et al. track newly specified blood progenitors in the dorsal aorta of the mouse embryo and demonstrate that they are polyclonal in origin and that hundreds of mesodermal, endothelial and blood precursors establish lifelong haematopoiesis.

  7. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling AOP

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    McNally et al. identify the retriever complex as required for endosomal cargo recycling. Retriever binds SNX17, the CCC and WASH complexes to govern cell surface expression of integrins, receptors and transporters.

  8. A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 AOP

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    Lee et al. found that the ubiquitin-editing enzyme A20 promotes TGF-β1-induced EMT and metastases of breast cancer cells via ubiquitylation-mediated nuclear stabilization of Snail1.

  9. Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1 AOP

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    Zhuang et al. show that breast-cancer-secreted DKK1, while promoting bone metastases via canonical WNT signalling, inhibits lung metastasis by antagonizing non-canonical Wnt signalling to suppress recruitment of anti-tumour immune cells.

  10. Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle AOP

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    Roman et al. demonstrate that crosslinking and contraction of myofibrils mediate the movement of nuclei to the periphery of myofibres, and describe a role for Arp2/3 in organizing desmin.

  11. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome AOP

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    Shi et al. map the ciliary transition zone by STORM imaging, characterizing protein arrangements in nested rings and finding that mutations in RPGRIP1L that are associated with the ciliopathy Joubert syndrome disrupt SMO ciliary localization.

  12. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

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    Skamagki et al. show that pluripotency factor ZSCAN10 is poorly expressed in iPSCs derived from aged donors, and its addition during reprogramming restores the DNA damage response and genomic stability through normalization of ROS–glutathione levels.

    See also: News and Views by Clea Bárcena et al.

  13. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

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    Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects.

    See also: News and Views by Brent E. Fitzwalter et al.

  14. Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

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    Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.

  15. SMC complexes differentially compact mitotic chromosomes according to genomic context

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    Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.

  16. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

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    Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.

    See also: Article by Aimee Flores et al.

  17. Lactate dehydrogenase activity drives hair follicle stem cell activation

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    Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.

    See also: Article by John C. Schell et al.

  18. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

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    Hiraike et al. identify nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat. NFIA activates cell-type-specific enhancers prior to differentiation and facilitates PPARγ binding to regulate the brown fat gene program.

    See also: News and Views by Suzanne N. Shapira et al.

  19. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

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    Glück et al. find that the DNA-sensing component cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments produced in senescent cells leading to STING-mediated production of SASPs, which promotes paracrine senescence.

    See also: News and Views by Marina Ruiz de Galarreta et al.