Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationArticles
Arginine methylation regulates the p53 response
Martin Jansson, Stephen T. Durant, Er-Chieh Cho, Sharon Sheahan, Mariola Edelmann, Benedikt Kessler & Nicholas B. La Thangue
Published online: 16 November 2008; | doi:10.1038/ncb1802
The tumour suppressor p53 is subject to complex regulation and arginine methylation is now shown to provide an additional level of control. The protein arginine methyltransferase (PRMT) 5 is recruited by Strap to methylate p53 in response to DNA damage, governing the p53 response.
Abstract - Arginine methylation regulates the p53 response | Full Text - Arginine methylation regulates the p53 response | PDF (1,825 KB) - Arginine methylation regulates the p53 response | Supplementary information
Fluctuations of intracellular forces during cell protrusion
Lin Ji, James Lim & Gaudenz Danuser
Published online: 16 November 2008; | doi:10.1038/ncb1797
Modelling intracellular force variations at cell protrusions suggests that cell adhesion is regulated at the interface between vinculin and integrin and reveals a putative feedback between increases in tension and F-actin assembly.
Abstract - Fluctuations of intracellular forces during cell protrusion | Full Text - Fluctuations of intracellular forces during cell protrusion | PDF (8,592 KB) - Fluctuations of intracellular forces during cell protrusion | Supplementary information
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
Jakob Nilsson, Mona Yekezare, Jeremy Minshull & Jonathon Pines
Published online: 09 November 2008; | doi:10.1038/ncb1799
Ubiquitin-dependent degradation of Cdc20 by the APC/C ligase is a conserved mechanism essential for maintaining the spindle assembly checkpoint activated by unattached chromosomes.
Abstract - The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | Full Text - The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | PDF (2,383 KB) - The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | Supplementary information
Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis
Matteo Rauzi, Pascale Verant, Thomas Lecuit & Pierre-François Lenne
Published online: 02 November 2008; | doi:10.1038/ncb1798
Quantitative analysis and mathematical modelling show that cortical tension anisotropy at apical cell junctions drives cell neighbour exchanges that are responsible for elongation of Drosophila embryos. This anisotropy depends on myosin II activity.
Abstract - Nature and anisotropy of cortical forces orienting : Drosophila: tissue morphogenesis | Full Text - Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis | PDF (4,723 KB) - Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis | Supplementary information
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic 
cells
Thomas F.J. Wagner, Sabine Loch, Sachar Lambert, Isabelle Straub, Stefanie Mannebach, Ilka Mathar, Martina Düfer, Annette Lis, Veit Flockerzi, Stephan E. Philipp & Johannes Oberwinkler
Published online: 02 November 2008; | doi:10.1038/ncb1801
In an unanticipated cross-talk between the steroid and insulin endocrine systems, the neuroactive steroid pregnenolone sulphate is found to activate the TRPM3 channel, leading to enhanced insulin secretion from pancreatic islets.
Abstract - Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic [beta] cells | Full Text - Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic 
cells | PDF (4,028 KB) - Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic cells | Supplementary information
Letters
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
Taner Dogan, Gregory S. Harms, Mirko Hekman, Christiaan Karreman, Tripat Kaur Oberoi, Emad S. Alnemri, Ulf R. Rapp & Krishnaraj Rajalingam
Published online: 16 November 2008; | doi:10.1038/ncb1804
The anti-apoptotic regulators XIAP and c-IAPs promote turnover of the cRAF kinase to control cell migration. XIAP binding facilitates ubiquitylation of cRAF through the ubiquitin ligase CHIP.
Abstract - X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility | Full Text - X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility | PDF (4,525 KB) - X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility | Supplementary information
Regulation of the Drosophila apoptosome through feedback inhibition
Peter J. Shapiro, Hans H. Hsu, Heekyung Jung, Edith S. Robbins & Hyung Don Ryoo
Published online: 16 November 2008; | doi:10.1038/ncb1803
The apoptotic inhibitor IAP1 regulates a feedback loop between the caspase Dronc1 and its apoptosome adaptor Apaf1 to maintain low caspase activity in cells that are not destined to die.
First Paragraph - Regulation of the : Drosophila: apoptosome through feedback inhibition | Full Text - Regulation of the Drosophila apoptosome through feedback inhibition | PDF (2,115 KB) - Regulation of the Drosophila apoptosome through feedback inhibition | Supplementary information
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Johan Skog, Tom Würdinger, Sjoerd van Rijn, Dimphna H. Meijer, Laura Gainche, William T. Curry, Jr., Bob S. Carter, Anna M. Krichevsky & Xandra O. Breakefield
Published online: 16 November 2008; | doi:10.1038/ncb1800
Human glioblastoma cells release microvesicles containing a diverse set of proteins, miRNAs and mRNAs, which can be taken up by normal host cells that translate the mRNA. Glioma-derived microvesicles carrying the specific tumour markers EGFRvIII and miRNA-21 promote cell proliferation and may serve as a diagnostic tool.
First Paragraph - Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | Full Text - Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | PDF (1,380 KB) - Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | Supplementary information
An H+ P-ATPase on the tonoplast determines vacuolar pH and flower colour
Walter Verweij, Cornelis Spelt, Gian-Pietro Di Sansebastiano, Joop Vermeer, Lara Reale, Francesco Ferranti, Ronald Koes & Francesca Quattrocchio
Published online: 09 November 2008; | doi:10.1038/ncb1805
P-ATPases in plants are typically thought to act at the plasma membrane. In contrast, PH5, a P-type H+ ATPase functions within the vacuolar membrane to control acidification during flower coloration.
First Paragraph - An H: +: P-ATPase on the tonoplast determines vacuolar pH and flower colour | Full Text - An H+ P-ATPase on the tonoplast determines vacuolar pH and flower colour | PDF (1,949 KB) - An H+ P-ATPase on the tonoplast determines vacuolar pH and flower colour | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Cell Biology advance online publication, day month year (doi:10.1038/ncbXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Cell Biology volume, page (year); advance online publication, (doi:10.1038/ncbXXXXX)".
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