1. Frederic Wissler and Michel Laouesse are at the IGBMC, CNRS/INSERM/ ULP, 1 rue Laurent Fries, BP 10142, 67400 Illkirch, France e-mail: lmichel@igbmc.u-strasbg.fr

Abstract

The evolutionarily conserved PAR3–PAR6–aPKC–Cdc42 complex has a well-established role in cell polarity. The exact job of PAR proteins in polarity is not known, but the finding that they affect endocytosis casts new light on their function.

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