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Letter

Nature Cell Biology 9, 945–953 (1 August 2007) | doi:10.1038/ncb1620

Regulated ATP release from astrocytes through lysosome exocytosis

Zhijun Zhang , Gang Chen , Wei Zhou , Aihong Song , Tao Xu , Qingming Luo , Wei Wang , Xiao-song Gu & Shumin Duan

Release of ATP from astrocytes is required for Ca2+ wave propagation among astrocytes and for feedback modulation of synaptic functions. However, the mechanism of ATP release and the source of ATP in astrocytes are still not known.