1. Yuliya Pylayeva is in the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, and the Sloan-Kettering Division, Weill Graduate School of Medical Sciences, Cornell University, 15 East 69th Street, New York, NY 10021, USA.
2. Filippo G. Giancotti is in the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. e-mail: f-giancotti@ski.mskcc.org

Abstract

The molecular mechanisms through which the epidermal growth factor receptor (EGFR) promotes normal cell migration and carcinoma invasion are incompletely understood. A new study reveals that EGFR induces a switch in expression from tensin to its endogenous inhibitor cten (C-terminal tensin-like protein), alleviating integrin linkage to the cytoskeleton. Analysis of clinical samples suggests that this may be important for breast cancer invasion.

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NPG Journals

by Subject Area

• Chemistry

  • Chemistry
  • Drug discovery
  • Biotechnology
  • Materials
  • Methods & Protocols

• Clinical Practice & Research

  • Cancer
  • Cardiovascular medicine
  • Dentistry
  • Endocrinology
  • Gastroenterology & Hepatology
  • Methods & Protocols
  • Pathology & Pathobiology
  • Urology

• Earth & Environment

  • Earth sciences
  • Evolution & Ecology

• Life sciences

  • Biotechnology
  • Cancer
  • Development
  • Drug discovery
  • Evolution & Ecology
  • Genetics
  • Immunology
  • Medical research
  • Methods & Protocols
  • Microbiology
  • Molecular cell biology
  • Neuroscience
  • Pharmacology
  • Systems biology

• Physical sciences

  • Physics
  • Materials

by A - Z Index