1. Anne K. Kenworthy is in the Departments of Molecular Physiology and Biophysics and Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, TN 37232, USA. e-mail: anne.kenworthy@vanderbilt.edu

Abstract

Membrane microdomains are widely postulated to regulate cell signalling, especially at the plasma membrane. Despite intense study, how this occurs remains largely unknown. New work now suggests that for MAP (mitogen-activated protein) kinase signalling, microdomains containing Ras nanoclusters contribute to the fidelity of signal transduction by acting as digital switches.

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