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Nature Cell Biology 9, 873 - 875 (2007)
doi:10.1038/ncb0807-873
PIM1 and MYC: a changing relationship?
Jean-Francois Naud1 & Martin Eilers1
- Jean-Francois Naud and Martin Eilers are at the Institute of Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Emil-Mannkopff-Strasse 2, 35033 Marburg, Germany e-mail: eilers@imt.uni-marburg.de
Abstract
PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates serine 10 of histone H3 at MYC target genes. These results may shed new mechanistic light on how PIM1 cooperates with MYC in tumorigenesis.
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RESEARCH
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