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Nature Cell Biology 9, 869 - 870 (2007)
doi:10.1038/ncb0807-869
GAPDH and the search for alternative energy
- Shiwei Song and Toren Finkel are in the Cardiology Branch, NHLBI, NIH Bethesda, Bldg 10/CRC 5-3330, 10 Center Drive, Bethesda, MD 20892, USA. e-mail: finkelt@nih.gov
Abstract
Permeabilization of the mitochondria usually leads to caspase activation and apoptosis. In the absence of caspase activation, these same mitochondrial changes can also lead to cell death. A recent study suggests that when good mitochondria go bad, the activation of both glycolysis and autophagy may permit cellular survival.
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