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Letter
Nature Cell Biology 9, 838–846 (1 July 2007) | doi:10.1038/ncb1610
Filamin-A regulates actin-dependent clustering of HIV receptors
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Abstract
Human immunodeficiency virus (HIV)-1 infection requires envelope (Env) glycoprotein gp120-induced clustering of CD4 and coreceptors (CCR5 or CXCR4) on the cell surface; this enables Env gp41 activation and formation of a complex that mediates fusion between Env-containing and target-cell membranes. Kinetic studies show that viral receptors are actively transported to the Env-receptor interface in a process that depends on plasma membrane composition and the actin cytoskeleton.
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