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Letter
Nature Cell Biology 9, 832–837 (1 July 2007) | doi:10.1038/ncb1609
Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis
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Abstract
In dividing cells, kinetochores couple chromosomes to the tips of growing and shortening microtubule fibres and tension at the kinetochore–microtubule interface promotes fibre elongation. Tension-dependent microtubule fibre elongation is thought to be essential for coordinating chromosome alignment and separation, but the mechanism underlying this effect is unknown.
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