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Nature Cell Biology 9, 729–731 (1 July 2007) | doi:10.1038/ncb0707-729

MYC degradation: deubiquitinating enzymes enter the dance

Bruno Amati & Victor J. Sanchez-Ar|[eacute]|valo Lobo

Making too much or too little of a regulatory protein in any cell of the body can have dire consequences for complex organisms. This is particularly evident for the products of oncogenes or tumour suppressor genes.