News and Views
Nature Cell Biology 9, 736 - 738 (2007)
doi:10.1038/ncb0707-736
Centriole biogenesis: a tale of two pathways
Jadranka Loncarek1, Greenfield Sluder2 & Alexey Khodjakov1
- Jadranka Loncarek and Alexey Khodjakov are in the Division of Molecular Medicine, Wadsworth Center, Albany NY 12201–0509, USA. e-mail: khodj@wadsworth.org
- Greenfield Sluder is in the Department of Cell Biology, University of Massachusetts Medical School, Worcester MA 01605, USA. e-mail: Greenfield.Sluder@umassmed.edu
Abstract
Two recent studies in Drosophila demonstrate that overexpression of proteins required for centriole duplication can not only induce centriole over-duplication in cells containing centrioles, but can also drive de novo centriole assembly in unfertilized eggs that initially lack centrioles. These studies offer a new perspective on the mechanisms that control centriole duplication.
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