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Nature Cell Biology 9, 729 - 731 (2007)
doi:10.1038/ncb0707-729
MYC degradation: deubiquitinating enzymes enter the dance
Bruno Amati1 & Victor J. Sanchez-Arévalo Lobo1
- Bruno Amati and Victor J. Sanchez-Arevalo Lobo are at the Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Milan 20139, Italy. e-mail: bruno.amati@ifom-ieo-campus.it
Abstract
Degradation of the MYC oncoprotein through site-specific phosphorylation and recognition by the ubiquitin ligase Fbw7 is central for controlling cell growth and tumorigenesis. New work adds another layer of complexity by showing that the deubiquitinating enzyme Usp28 'piggybacks' on the nuclear isoform of the ligase and stabilizes MYC, thus explaining the selective degradation of MYC in the nucleolus.
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