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Letter

Nature Cell Biology 9, 666–674 (1 June 2007) | doi:10.1038/ncb1597

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui Denecker , Esther Hoste , Barbara Gilbert , Tino Hochepied , Petra Ovaere , Saskia Lippens , Caroline Van den Broecke , Petra Van Damme , Katharina D'Herde , Jean-Pierre Hachem , Gaetan Borgonie , Richard B. Presland , Luc Schoonjans , Claude Libert , Jo|[euml]|l Vandekerckhove , Kris Gevaert , Peter Vandenabeele & Wim Declercq

Caspase-14 belongs to a conserved family of aspartate-specific proteinases. Its expression is restricted almost exclusively to the suprabasal layers of the epidermis and the hair follicles.