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Letter
Nature Cell Biology 9, 596–603 (1 May 2007) | doi:10.1038/ncb1572
N-terminal |[alpha]|-methylation of RCC1 is necessary for stable chromatin association and normal mitosis
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Abstract
Regulator of chromatin condensation 1 (RCC1) is the only known guanine nucleotide-exchange factor for the Ran GTPase and has pivotal roles in nucleo-cytoplasmic transport, mitosis, and nuclear-envelope assembly. RCC1 associates dynamically with chromatin through binding to histones H2A and/or H2B in a Ran-regulated manner.
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