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Nature Cell Biology 9, 487 - 489 (2007)
doi:10.1038/ncb0507-487

Mitochondrial apoptosis without VDAC

Lorenzo Galluzzi1 & Guido Kroemer1

  1. Lorenzo Galluzzi and Guido Kroemer are in the INSERM, U848 94805 Villejuif, France; the Institut Gustave Roussy, 94805 Villejuif, France; and the Université Paris-Sud, Paris 11, 94805 Villejuif, France. e-mail: kroemer@igr.fr

Voltage-dependent anion channels (VDACs) are thought to participate in mitochondrial-membrane permeabilization, an event that frequently delimits the frontier between cell life and death. Recent work casts doubts on their contribution to mitochondrial cell death.

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